Document Detail


Education and the risk of Alzheimer's disease: findings from the study of dementia in Swedish twins.
MedLine Citation:
PMID:  11522804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between dementia and education was studied in 143 twin pairs discordant for dementia, using a matched-pair design, and in 221 dementia cases and 442 unrelated controls from the same twin registry, using a case-control design. Low education was defined as 6 years or less of schooling. Case-control analyses with prevalent cases showed low education to be a risk for Alzheimer's disease but not dementia in general. Low education did not significantly predict incident cases. In the matched-pairs analysis, which controls for genetic and other familial influences, differences in education between demented twins and twin partners were not statistically significant. However, for Alzheimer's disease, odds ratios resulting from matched pairs and case-control analyses were similar. Twins' comparative reports about intellectual involvement earlier in their lives suggest a long-standing difference on this dimension, with less involvement by the twin who became demented.
Authors:
M Gatz; P Svedberg; N L Pedersen; J A Mortimer; S Berg; B Johansson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Twin Study    
Journal Detail:
Title:  The journals of gerontology. Series B, Psychological sciences and social sciences     Volume:  56     ISSN:  1079-5014     ISO Abbreviation:  J Gerontol B Psychol Sci Soc Sci     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-09-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9508483     Medline TA:  J Gerontol B Psychol Sci Soc Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  P292-300     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA. GATZ@rcf.usc.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / diagnosis,  epidemiology,  genetics*
Case-Control Studies
Causality
Diseases in Twins / genetics*
Educational Status*
Female
Genetic Predisposition to Disease / genetics
Geriatric Assessment
Humans
Male
Matched-Pair Analysis
Risk
Sweden
Grant Support
ID/Acronym/Agency:
AG04563/AG/NIA NIH HHS; AG08861/AG/NIA NIH HHS; AG10175/AG/NIA NIH HHS; R01-AG08724/AG/NIA NIH HHS
Comments/Corrections
Erratum In:
J Gerontol B Psychol Sci Soc Sci. 2004 Jan;59(1):P34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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