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Education, Genetic Ancestry, and Blood Pressure in African Americans and Whites.
MedLine Citation:
PMID:  22698014     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives. We assessed the relative roles of education and genetic ancestry in predicting blood pressure (BP) within African Americans and explored the association between education and BP across racial groups. Methods. We used t tests and linear regressions to examine the associations of genetic ancestry, estimated from a genomewide set of autosomal markers, and education with BP variation among African Americans in the Family Blood Pressure Program. We also performed linear regressions in self-identified African Americans and Whites to explore the association of education with BP across racial groups. Results. Education, but not genetic ancestry, significantly predicted BP variation in the African American subsample (b = -0.51 mm Hg per year additional education; P = .001). Although education was inversely associated with BP in the total population, within-group analyses showed that education remained a significant predictor of BP only among the African Americans. We found a significant interaction (b = 3.20; P = .006) between education and self-identified race in predicting BP. Conclusions. Racial disparities in BP may be better explained by differences in education than by genetic ancestry. Future studies of ancestry and disease should include measures of the social environment. (Am J Public Health. Published online ahead of print June 14, 2012: e1-e7. doi:10.2105/AJPH.2011.300448).
Authors:
Amy L Non; Clarence C Gravlee; Connie J Mulligan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-14
Journal Detail:
Title:  American journal of public health     Volume:  -     ISSN:  1541-0048     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Amy L. Non is a Robert Wood Johnson Foundation Health and Society Scholar at Harvard University in Cambridge, MA. Clarence C. Gravlee and Connie J. Mulligan are with the Department of Anthropology at the University of Florida, Gainesville. Connie J. Mulligan is also with the Genetics Institute, University of Florida, Gainesville.
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