Document Detail


Education, genetic ancestry, and blood pressure in African Americans and Whites.
MedLine Citation:
PMID:  22698014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We assessed the relative roles of education and genetic ancestry in predicting blood pressure (BP) within African Americans and explored the association between education and BP across racial groups.
METHODS: We used t tests and linear regressions to examine the associations of genetic ancestry, estimated from a genomewide set of autosomal markers, and education with BP variation among African Americans in the Family Blood Pressure Program. We also performed linear regressions in self-identified African Americans and Whites to explore the association of education with BP across racial groups.
RESULTS: Education, but not genetic ancestry, significantly predicted BP variation in the African American subsample (b=-0.51 mm Hg per year additional education; P=.001). Although education was inversely associated with BP in the total population, within-group analyses showed that education remained a significant predictor of BP only among the African Americans. We found a significant interaction (b=3.20; P=.006) between education and self-identified race in predicting BP.
CONCLUSIONS: Racial disparities in BP may be better explained by differences in education than by genetic ancestry. Future studies of ancestry and disease should include measures of the social environment.
Authors:
Amy L Non; Clarence C Gravlee; Connie J Mulligan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-06-14
Journal Detail:
Title:  American journal of public health     Volume:  102     ISSN:  1541-0048     ISO Abbreviation:  Am J Public Health     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-12     Completed Date:  2012-10-12     Revised Date:  2014-08-10    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1559-65     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Americans*
Aged
Aged, 80 and over
Blood Pressure / genetics*,  physiology
Educational Status*
European Continental Ancestry Group*
Female
Health Status Disparities
Humans
Hypertension / genetics*,  physiopathology
Linear Models
Male
Middle Aged
Young Adult
Grant Support
ID/Acronym/Agency:
HL45508/HL/NHLBI NIH HHS; HL47910/HL/NHLBI NIH HHS; HL54059/HL/NHLBI NIH HHS; HL54464/HL/NHLBI NIH HHS; HL54471/HL/NHLBI NIH HHS; HL54472/HL/NHLBI NIH HHS; HL54473/HL/NHLBI NIH HHS; HL54495/HL/NHLBI NIH HHS; HL54496/HL/NHLBI NIH HHS; HL54497/HL/NHLBI NIH HHS; HL54515/HL/NHLBI NIH HHS; R01 HL51021/HL/NHLBI NIH HHS; U10 HL54481/HL/NHLBI NIH HHS
Comments/Corrections

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