| Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide. | |
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MedLine Citation:
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PMID: 20880743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toll-like receptor (TLR) adjuvants are capable of driving T cell immunity. The TLR4 agonist LPS activates antigen-presenting cells through myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor inducing interferon-beta (TRIF)-dependent signaling pathways, initiating CD4 T helper cell clonal expansion and differentiation. Lipopolysaccharide (LPS) supports the development of diverse T helper (Th) lineages depending on the tissue microenvironment. For instance, peripheral immunization with LPS drives Th1 priming in lymphoid tissue and Th17 priming in the gut. This could be due to commensal bacteria inducing Th17-stabilizing cytokines within the intestinal lamina propria. Here, we detail how the response to LPS stimulates CD4 T cell priming in lymphoid tissue and the intestinal mucosa. How this knowledge might be exploited to target specific features of T cell immunity by vaccine adjuvants is also considered. |
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Authors:
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Jeremy P McAleer; Anthony T Vella |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-09-27 |
Journal Detail:
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Title: Trends in immunology Volume: 31 ISSN: 1471-4981 ISO Abbreviation: Trends Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-12-02 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 429-35 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Immunology, MC1319, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology Animals CD4-Positive T-Lymphocytes / cytology, drug effects, immunology* Humans Lipopolysaccharides / immunology* Toll-Like Receptors / immunology Vaccines / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI042858-10/AI/NIAID NIH HHS; R01 AI042858-11/AI/NIAID NIH HHS; R01 AI052108-01A1/AI/NIAID NIH HHS; R01 AI42858/AI/NIAID NIH HHS; R01 AI52108/AI/NIAID NIH HHS; T32 AI007080-25A2/AI/NIAID NIH HHS; T32-AI07080/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Lipopolysaccharides; 0/Toll-Like Receptors; 0/Vaccines |
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