| PPIs and clopidogrel: the band plays on............ | |
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MedLine Citation:
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PMID: 21048683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Controversy currently surrounds the issue of proton pump inhibitor (PPI)-clopidogrel co-therapy. Some studies have reported that PPIs increase the rate of adverse cardiovascular outcomes in clopidogrel users, although others have not confirmed this. The Food and Drug Administration has advised against the use of certain PPIs by patients who are on clopidogrel. In the first outcomes study from Europe to examine this issue, van Boxel and colleagues found an increased rate of adverse cardiovascular--and gastrointestinal--outcomes among clopidogrel users taking a PPI. The most plausible explanation for this is that it reflects channeling bias. |
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Authors:
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Colin W Howden |
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Publication Detail:
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Type: Comment; Editorial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 105 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-04 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 2438-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bias (Epidemiology) Drug Interactions Humans Platelet Aggregation Inhibitors / adverse effects Proton Pump Inhibitors / adverse effects* Retrospective Studies Risk Factors Ticlopidine / adverse effects, analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 0/Proton Pump Inhibitors; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel |
| Comments/Corrections | |
Comment On:
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Am J Gastroenterol. 2010 Nov;105(11):2430-6; quiz 2437
[PMID:
20736935
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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