Document Detail

PPIs and clopidogrel: the band plays on............
MedLine Citation:
PMID:  21048683     Owner:  NLM     Status:  MEDLINE    
Controversy currently surrounds the issue of proton pump inhibitor (PPI)-clopidogrel co-therapy. Some studies have reported that PPIs increase the rate of adverse cardiovascular outcomes in clopidogrel users, although others have not confirmed this. The Food and Drug Administration has advised against the use of certain PPIs by patients who are on clopidogrel. In the first outcomes study from Europe to examine this issue, van Boxel and colleagues found an increased rate of adverse cardiovascular--and gastrointestinal--outcomes among clopidogrel users taking a PPI. The most plausible explanation for this is that it reflects channeling bias.
Colin W Howden
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  105     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-04     Completed Date:  2010-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2438-9     Citation Subset:  IM    
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MeSH Terms
Bias (Epidemiology)
Drug Interactions
Platelet Aggregation Inhibitors / adverse effects
Proton Pump Inhibitors / adverse effects*
Retrospective Studies
Risk Factors
Ticlopidine / adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 0/Proton Pump Inhibitors; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel
Comment On:
Am J Gastroenterol. 2010 Nov;105(11):2430-6; quiz 2437   [PMID:  20736935 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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