Document Detail

Editorial: Exercise for NAFLD: does intensity matter?
MedLine Citation:
PMID:  21378763     Owner:  NLM     Status:  MEDLINE    
Currently, there are no established means for the prevention or treatment of non-alcoholic steatohepatitis (NASH) despite our increasing understanding of nonalcoholic fatty liver disease (NAFLD) pathogenesis implicating insulin resistance (IR) as a key factor and highlighting the central role of lipotoxic liver injury in the development of NASH. Lifestyle interventions aiming at decreasing IR and preventing lipotoxicity, including weight loss, diet, and physical exercise, are in the frontline for NASH patient management. Physical activity may ameliorate IR, maintain weight loss, and improve liver histology in NASH patients. However, there are no recognized criteria for the optimal intensity, duration, or total volume of exercise needed to obtain these beneficial effects. In this issue of the American Journal of Gastroenterology, Kistler and colleagues show that vigorous, but not moderate exercise, nor total duration or volume of physical activity, is related to decreased odds of having NASH or advanced fibrosis. Prospective studies using the objective criteria of physical activity, addressing the role of concurrent weight loss, and assessing individual histological features are needed to further clarify the effects of exercise intensity on NAFLD histology.
Hari S Conjeevaram; Dina G Tiniakos
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  106     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-04-28     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-5     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Diet, Reducing
Fatty Liver* / pathology
Food Habits*
Life Style*
Liver Cirrhosis / pathology
Motor Activity
Severity of Illness Index
Weight Loss
Comment On:
Am J Gastroenterol. 2011 Mar;106(3):460-8; quiz 469   [PMID:  21206486 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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