| Edema induction by the disintegrin-like/cysteine-rich domains from a Bothrops atrox hemorrhagin. | |
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MedLine Citation:
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PMID: 11006077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Viperine and crotaline snake venoms contain one or more hemorrhagic metalloproteases called hemorrhagins. The most potent hemorrhagins belong to the P-III class and have, in addition to the protease domain, disintegrin-like and cysteine-rich domains. Although proteolytic degradation of vascular endothelium basement membrane has been established to be the main factor responsible for hemorrhage, several studies reveal other factors that actually do facilitate this process. Recent evidence has shown that the nonprotease domains of the P-III class hemorrhagins are able to inhibit the platelet aggregation by blocking essential procoagulant integrins on platelets. In this study we report the identification of a hemorrhagin from Bothrops atrox venom. This enzyme, a P-III class metalloprotease, undergoes an apparent spontaneous degradation, releasing a proteic fragment containing the disintegrin-like/cysteine-rich domains. This fragment shows the capability to induce an edematogenic process, suggesting the existence of a still unknown nonenzymatic mechanism of vascular permeability increase. |
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Authors:
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J H Petretski; M M Kanashiro; F R Rodrigues; E W Alves; O L Machado; T L Kipnis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 276 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-10-26 Completed Date: 2000-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 29-34 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense, Av. Alberto Lamego, 2000, Campos dos Goytacazes, Rio de Janiero, Cep 28015-620, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Bothrops Crotalid Venoms* Cysteine Disintegrins / toxicity* Edema / chemically induced* Endopeptidases / chemistry, genetics, toxicity* Mice Mice, Inbred BALB C Molecular Sequence Data Platelet Aggregation Inhibitors / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Crotalid Venoms; 0/Disintegrins; 0/Platelet Aggregation Inhibitors; 52-90-4/Cysteine; EC 3.4.-/Endopeptidases; EC 3.4.-/hemorrhagic proteinase IV |
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