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Ed focus- F-676-2013 The slowing down of renal deterioration but acceleration of cardiac hypertrophy-is estrogen receptor α a hero or villain?
MedLine Citation:
PMID:  25350979     Owner:  NLM     Status:  Publisher    
Role of estrogen receptor α (ERα) in the kidney and heart was still uncertain, although Estrogen-ER action is usually thought to function as reno- and possibly cardio-protection, which includes prevention of glomerulosclerosis and podocyte apoptosis in kidney, and atheroprotection by lowering plague formation and against endothelial dysfunction after injury, ischemia and re-perfusion. The adenine-fed rat model of Diwan showed that an adenine diet significantly decreased ERα expression in male rat kidney, but significantly increased ERα expression in the heart of both genders. Their results regarding renal function showed male adenine-fed rats had significantly more kidney function decline than female adenine-fed rats, suggesting the favorable role of ERα in the kidney. However, the results of an increased expression of ERα in the heart should be read with caution. Since an increased expression of ERα and the subsequently activating the extracellular signal-regulated kinase (ERK1/2) pathway may be attributed partly to cardiac hypertrophy. Cardiac hypertrophy, a compensation for the contraction ability of the heart, might transiently maintain the "normal" heart function; therefore, is a hero for the heart. However, cardiac hypertrophy may increase the burden of oxygen consumption and further exacerbate the severity of existence of ischemic heart disease or even worsen the "normal heart". Therefore, the net long-term effect of ERα might not be good for the heart itself.
Ben-Shian Huang; Wen-Ling Lee; Peng-Hui Peter Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-1
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  -     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-28     Completed Date:  -     Revised Date:  2014-10-29    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  ajprenal.00529.2014     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Renal Physiology.
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