| Eczema craquelé with purpura: a sign of internal malignancy or malabsorption syndrome? | |
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MedLine Citation:
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PMID: 19326691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient with eczema craquelé associated with adenocarcinoma of the pancreas. Following a Whipple operation, zinc malabsorption was ruled out as the cause based on the distribution of the dermatitis, alkaline phosphatase levels within reference range, and response to pancreatic enzyme replacement therapy. Because the patient's skin changes appeared following removal of the malignancy and resolved shortly after the second course of pancreatic enzyme replacement therapy, fat malabsorption probably was responsible for the skin changes rather than a direct paraneoplastic expression of the cancer. The occurrence of purpura with eczema craquele has not been previously described in the literature. These findings raise the possibility that generalized eczema craquele is a diagnostic clue to a malignancy and argue for adding it to the list of cutaneous paraneoplastic syndromes. |
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Authors:
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Oliver Kraigher; Sarah Brenner |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cutis; cutaneous medicine for the practitioner Volume: 83 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-05-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006440 Medline TA: Cutis Country: United States |
Other Details:
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Languages: eng Pagination: 75-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel. kraighero@012.net.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis*,
surgery Diagnosis, Differential Eczema / complications, diagnosis*, therapy Humans Malabsorption Syndromes / diagnosis Male Middle Aged Pancreatic Neoplasms / diagnosis*, surgery Purpura / complications, diagnosis*, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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