Document Detail


Ectosomes as modulators of inflammation and immunity.
MedLine Citation:
PMID:  21039423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vesicles released by cells have been described using various names, including exosomes, microparticles, microvesicles and ectosomes. Here we propose to differentiate clearly between ectosomes and exosomes according to their formation and release. Whereas exosomes are formed in multi-vesicular bodies, ectosomes are vesicles budding directly from the cell surface. Depending upon the proteins expressed, exosomes activate or inhibit the immune system. One of the major properties of exosomes released by antigen-presenting cells is to induce antigen-specific T cell activation. Thus, they have been used for tumour immunotherapy. By contrast, the major characteristics of ectosomes released by various cells, including tumour cells, polymorphonuclear leucocytes and erythrocytes, are the expression of phosphatidylserine and to have anti-inflammatory/immunosuppressive activities similarly to apoptotic cells.
Authors:
S Sadallah; C Eken; J A Schifferli
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-29
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  163     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-01     Completed Date:  2010-12-30     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  26-32     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.
Affiliation:
Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Antigen-Presenting Cells / immunology
Apoptosis / immunology
Cell-Derived Microparticles / immunology*
Erythrocytes / immunology
Exosomes / immunology*
Humans
Immunity*
Immunotherapy
Inflammation / immunology*
Lymphocyte Activation / immunology
Neoplasms / immunology
Neutrophils / immunology
Phosphatidylserines / immunology
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/Phosphatidylserines
Comments/Corrections

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