Document Detail

Ectopic thymus presenting as a thyroid nodule in a patient with the Carney complex.
MedLine Citation:
PMID:  19265501     Owner:  NLM     Status:  MEDLINE    
Ectopic thymic tissue within the thyroid gland is rare. Patients with a complex of myxomas, spotty skin pigmentation, and endocrine overactivity, collectively known as Carney complex (CNC), have a predisposition towards the development of thyroid abnormalities, but there are no reports of thymic defects in CNC. We present the case of a 12-year-old boy with CNC and a growing thyroid nodule. The patient had the c.682 C > T (Arg228X) pathogenic PRKAR1A mutation. Hemithyroidectomy for a Hürthle cell adenoma led to the confirmation of distinct intrathyroidal ectopic thymic tissue. Thymic abnormalities have not been previously reported in CNC.
Nickolas Courcoutsakis; Nickolas Patronas; Armando C Filie; J Aidan Carney; Andreas Moraitis; Constantine A Stratakis
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  19     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-06     Completed Date:  2009-05-04     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Adenoma, Oxyphilic / pathology
Choristoma / pathology*
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit / genetics
DNA / biosynthesis,  genetics
Diagnosis, Differential
In Situ Hybridization, Fluorescence
Lentigo / complications,  pathology*
Multiple Endocrine Neoplasia / complications,  pathology*
Pigmentation Disorders / complications,  pathology*
Thymus Gland / pathology*
Thyroid Nodule / pathology*
Grant Support
Z01-HD-000642-04/HD/NICHD NIH HHS
Reg. No./Substance:
0/Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0/PRKAR1A protein, human; 9007-49-2/DNA

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