Document Detail

Ectopic pregnancy with undetectable serum and urine beta-hCG levels and detection of beta-hCG in the ectopic trophoblast by immunocytochemical evaluation.
MedLine Citation:
PMID:  7682319     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ectopic pregnancies associated with negative urine or serum pregnancy test by radioimmunoassay usually demonstrate either nonviable trophoblast or absent production of beta-hCG by the ectopic pregnancy. CASE: We report a patient with intra-abdominal hemorrhage caused by a ruptured ampullary ectopic pregnancy who had undetectable serum and urine beta-hCG levels (less than 5 mIU/mL). Immunoperoxidase staining of the ectopic trophoblastic tissue obtained at surgery revealed both beta-hCG and placental alkaline phosphatase. CONCLUSION: Negative serum and urine pregnancy tests can occur even though beta-hCG produced by the viable ectopic trophoblastic tissue can be demonstrated by immunoperoxidase staining.
M L Maccato; R Estrada; S Faro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  81     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-05-13     Completed Date:  1993-05-13     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  878-80     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
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MeSH Terms
Chorionic Gonadotropin / analysis*
Chorionic Gonadotropin, beta Subunit, Human
Gastrointestinal Hemorrhage / etiology
Immunoenzyme Techniques
Peptide Fragments / analysis*
Pregnancy Tests
Pregnancy, Tubal / diagnosis*
Rupture, Spontaneous
Trophoblasts / chemistry*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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