Document Detail


Ectopic pregnancy and emergency contraceptive pills: a systematic review.
MedLine Citation:
PMID:  20502299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the existing data to estimate the rate of ectopic pregnancy among emergency contraceptive pill treatment failures.
DATA SOURCES: Our initial reference list was generated from a 2008 Cochrane review of emergency contraception. In August 2009, we searched Biosys Previews, the Cochrane Database of Systematic Reviews, Medline, Global Health Database, Health Source: Popline, and Wanfang Data (a Chinese database).
METHODS: This study included data from 136 studies, which followed a defined population of women treated one time with emergency contraceptive pills (either mifepristone or levonorgestrel) and in which the number and location of pregnancies were ascertained.
RESULTS: Data from each article were abstracted independently by two reviewers. In the studies of mifepristone, 3 of 494 (0.6%) pregnancies were ectopic; in the levonorgestrel studies, 3 of 307 (1%) were ectopic.
CONCLUSION: The rate of ectopic pregnancy when treatment with emergency contraceptive pills fails does not exceed the rate observed in the general population. Because emergency contraceptive pills are effective in lowering the risk of pregnancy, their use will reduce the chance that an act of intercourse will result in ectopic pregnancy.
LEVEL OF EVIDENCE: III.
Authors:
Kelly Cleland; Elizabeth Raymond; James Trussell; Linan Cheng; Haoping Zhu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  115     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-07-01     Revised Date:  2014-02-28    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1263-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Contraceptives, Postcoital*
Female
Humans
Levonorgestrel
Mifepristone
Pregnancy
Pregnancy, Ectopic / epidemiology*
Grant Support
ID/Acronym/Agency:
R24 HD047879/HD/NICHD NIH HHS; R24 HD047879-06/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Contraceptives, Postcoital; 320T6RNW1F/Mifepristone; 5W7SIA7YZW/Levonorgestrel
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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