Document Detail

Ectopic pregnancy after assisted reproductive technology: what are the risk factors?
MedLine Citation:
PMID:  20216415     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review discusses recent publications that investigate risk factors associated with ectopic pregnancy after IVF. RECENT FINDINGS: Data on the risk factors for developing ectopic pregnancy after IVF are still inconsistent. Between fresh nondonor IVF and embryo transfer cycles, the significant risk factor for ectopic pregnancy was tubal factor infertility, and endometriosis, rather than male factor infertility. Higher ectopic pregnancy rate could be associated with zygote intrafallopian transfer, assisted hatching, large embryo transfer volume, deep fundal transfer, and frozen embryo transfer. The supraphysiologic progesterone level may decrease uterine contractility and enhance implantation in the uterine cavity in fresh embryo transfer compared with frozen embryo transfer cycles. Although recent results suggest reassurance in risk of ectopic pregnancy with frozen transfer, clinicians should be remembering this possibility while performing a frozen embryo transfer. Higher implantation potential per embryo at the blastocyst stage may increase the risk of ectopic pregnancy than cleavage stage. Especially, according to numbers of embryos transferred, different risk of ectopic pregnancy after IVF was noted. SUMMARY: Different hormonal milieu, the reproductive health characteristics of infertile women such as distorted tubal function, technical issues of IVF procedures, and the estimated embryo implantation potential are possible risk factors. How each factor contributes to the risk of occurring ectopic pregnancy after assisted reproductive technology is uncertain and needs further investigation.
Hye Jin Chang; Chang Suk Suh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  22     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  202-7     Citation Subset:  IM    
Health Promotion Center, Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, South Korea.
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MeSH Terms
Endometriosis / complications
Fallopian Tube Diseases / complications
Infertility, Female / etiology,  therapy
Oocyte Donation
Pelvic Inflammatory Disease / complications
Pregnancy, Ectopic / epidemiology,  etiology*
Reproductive Techniques, Assisted / adverse effects*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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