Document Detail

Ectopic intestinal glands after segmental small bowel irradiation in the cat.
MedLine Citation:
PMID:  6328879     Owner:  NLM     Status:  MEDLINE    
Following segmental irradiation of the small bowel, 5 of 64 cats demonstrated ectopic intestinal glands in the submucosal tissue. In addition, one of these 5 cats had foci of abnormal glands in the muscularis mucosae. In 2 of the 5 animals, cellular polymorphism, nucleolar irregularity and loss of cellular polarity were present in irradiation-induced ectopic intestinal glands. The review of the literature indicates that intestinal irradiation may induce intestinal adenocarcinomas with metastatic growth. The possibility that ectopic intestinal glands are precancerous lesions in the irradiated cat is discussed.
C A Rubio; B Eriksson; L Johnsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica. Oncology     Volume:  22     ISSN:  0349-652X     ISO Abbreviation:  Acta Radiol Oncol     Publication Date:  1983  
Date Detail:
Created Date:  1984-07-06     Completed Date:  1984-07-06     Revised Date:  2006-12-05    
Medline Journal Info:
Nlm Unique ID:  8209606     Medline TA:  Acta Radiol Oncol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  473-5     Citation Subset:  IM    
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MeSH Terms
Cell Nucleolus / pathology
Cell Nucleus / pathology
Dose-Response Relationship, Radiation
Epithelium / pathology
Exocrine Glands / pathology*
Intestinal Diseases / etiology,  pathology
Intestinal Mucosa / pathology
Intestine, Small / pathology,  radiation effects*
Radiation Injuries, Experimental / etiology*,  pathology

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