| Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. | |
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MedLine Citation:
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PMID: 15592488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In humans and most animal models, the development of obesity leads not only to increased fat depots in classical adipose tissue locations but also to significant lipid deposits within and around other tissues and organs, a phenomenon known as ectopic fat storage. The purpose of this review is to explore the possible locations of ectopic fat in key target-organs of cardiovascular control (heart, blood vessels and kidneys) and to propose how ectopic fat storage can play a role in the pathogenesis of cardiovascular diseases associated with obesity. In animals fed a high-fat diet, cardiac fat depots within and around the heart impair both systolic and diastolic functions, and may in the long-term promote heart failure. Accumulation of fat around blood vessels (perivascular fat) may affect vascular function in a paracrine manner, as perivascular fat cells secrete vascular relaxing factors, proatherogenic cytokines and smooth muscle cell growth factors. Furthermore, high amounts of perivascular fat could mechanically contribute to the increased vascular stiffness seen in obesity. Finally, accumulation of fat in the renal sinus may limit the outflow of blood and lymph from the kidney, which would alter intrarenal physical forces and promote sodium reabsorption and arterial hypertension. Taken together, ectopic fat storage in key target-organs of cardiovascular control may impair their functions, contributing to the increased prevalence of cardiovascular diseases in obese subjects. |
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Authors:
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J-P Montani; J F Carroll; T M Dwyer; V Antic; Z Yang; A G Dulloo |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Volume: 28 Suppl 4 ISSN: 0307-0565 ISO Abbreviation: Int. J. Obes. Relat. Metab. Disord. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-05-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9313169 Medline TA: Int J Obes Relat Metab Disord Country: England |
Other Details:
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Languages: eng Pagination: S58-65 Citation Subset: IM |
Affiliation:
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Department of Medicine/Division of Physiology, University of Fribourg, Switzerland. jean-pierre.montani@unifr.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Animals Blood Vessels / metabolism* Cardiovascular Diseases / etiology*, metabolism, physiopathology Choristoma / metabolism Hemodynamics / physiology Humans Kidney / metabolism* Lipid Metabolism* Lipomatosis / metabolism, physiopathology Models, Biological Myocardium / metabolism* Obesity / complications, metabolism, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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