| Ectopic adrenocorticotropin syndrome caused by lung cancer that responded to corticotropin-releasing hormone. | |
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MedLine Citation:
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PMID: 3020074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ACTH responses to corticotropin-releasing hormone (CRH) were studied in three patients with the ectopic ACTH syndrome caused by lung cancer. Plasma ACTH responded to synthetic CRH in two of three patients. Tumor tissues obtained from these two patients contained CRH and ACTH. In one patient, tumor ACTH secretion was stimulated by CRH in vitro. Tumor CRH was immunologically, chromatographically, and biologically similar to hypothalamic CRH. In addition, multiple forms of immunoreactive beta-endorphin were present in plasma and the tumor extracts. From these results, we conclude that some patients with the ectopic ACTH syndrome have tumors that produce both ACTH and CRH and that CRH can stimulate ACTH secretion by such tumors. Other patients with the ectopic ACTH syndrome do not have ACTH responses to CRH. Therefore, procedures other than CRH testing are needed to differentiate patients with Cushing's syndrome due to ectopic ACTH/CRH production from those with Cushing's disease, since the latter also usually have ACTH responses to CRH. |
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Authors:
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T Suda; M Kondo; R Totani; N Hashimoto; M Suzuki; T Imaki; Y Oba; N Tomori; F Yajima; T Sumitomo |
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Publication Detail:
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Type: Case Reports; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 63 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1986-11-19 Completed Date: 1986-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1047-51 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ACTH Syndrome, Ectopic
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etiology* Aged Carcinoma, Small Cell / secretion Corticotropin-Releasing Hormone / physiology, secretion* Endorphins / blood Humans Lung Neoplasms / secretion* Male Middle Aged Paraneoplastic Endocrine Syndromes / etiology* Radioimmunoassay beta-Endorphin |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 60617-12-1/beta-Endorphin; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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