Document Detail

Ectopic extramammary Paget's disease: case report and literature review.
MedLine Citation:
PMID:  20814627     Owner:  NLM     Status:  MEDLINE    
Extramammary Paget's disease that occurs in non-apocrine-bearing regions is referred to as ectopic and has been rarely reported. A 62-year-old man presented with a slowly progressive, asymptomatic light-brown plaque on his back. Histopathological examination revealed the presence of large pale cells with prominent nuclei, which proliferated diffusely and focally in the epidermis. Immuno-histochemically the tumour cells were positive for CK7, GCDFP-15, CEA, and p63. Based on these findings, we diagnosed the tumour as ectopic extramammary Paget's disease. We reviewed the English and Japanese literature and found 29 previously reported cases of ectopic extramammary Paget's disease, including our case, with a predominance of occurrence in the Asian population. The germinative milk line is known to be a possible site where extramammary Paget's disease occurs. Like-wise, some germinative apocrine-differentiating cells might exist on the trunk preferentially in Asians. Attention should be paid to the development of ectopic as well as triple or quadruple EMPD in Asians.
Yu Sawada; Toshinori Bito; Rieko Kabashima; Ryutaro Yoshiki; Ryosuke Hino; Motonobu Nakamura; Masanori Shiraishi; Yoshiki Tokura
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  90     ISSN:  1651-2057     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-12-28     Revised Date:  2012-01-02    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  502-5     Citation Subset:  IM    
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Middle Aged
Paget Disease, Extramammary / chemistry,  diagnosis*,  ethnology,  pathology,  surgery
Skin / pathology
Skin Neoplasms / chemistry,  diagnosis*,  ethnology,  pathology,  surgery
Treatment Outcome
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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