Document Detail

Ectopic Cushing's syndrome due to an adrenal ganglioneuroma.
MedLine Citation:
PMID:  20389113     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cushing's syndrome (CS), rare in children, is due to pituitary or, less frequently, to adrenocortical tumors. Ectopic adrenocorticotropin (ACTH) secretion is exceptional.
METHOD: A case of apparently ACTH-independent CS in a child is reported.
RESULTS: CS was due to an adrenal ganglioneuroma where neuroendocrine cells were immunopositive for ACTH responsible for the syndrome through a paracrine effect. Cortical cell hyperplasia was observed.
CONCLUSION: Benign and differentiated tumors of the neural crest such as ganglioneuromas may be responsible for CS.
Jean-Benoît Corcuff; Colette Deminiere; Jacqueline Trouillas; Olivier Puel; Yves Perel; Pascal Barat
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-04-14
Journal Detail:
Title:  Hormone research in pædiatrics     Volume:  73     ISSN:  1663-2826     ISO Abbreviation:  Horm Res Paediatr     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-15     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101525157     Medline TA:  Horm Res Paediatr     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  405-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
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MeSH Terms
Adrenal Cortex Neoplasms / diagnosis,  pathology*
Adrenal Glands / pathology
Adrenocorticotropic Hormone / metabolism
Cushing Syndrome / diagnosis,  etiology*,  pathology
Ganglioneuroma / diagnosis,  pathology*
Hormones, Ectopic / metabolism
Reg. No./Substance:
0/Hormones, Ectopic; 9002-60-2/Adrenocorticotropic Hormone

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