Document Detail

Ecotoxicities of polyquaterniums and their associated polyelectrolyte-surfactant aggregates (PSA) to Gambusia holbrooki.
MedLine Citation:
PMID:  18172802     Owner:  NLM     Status:  MEDLINE    
The toxicity of 11 polyquaterniums used in cosmetic applications, and polydimethyldiallylammonium chloride (poly(DADMAC)) were studied for toxicity of the polyquaternium alone, and of a polyquaternium/anionic surfactant complex as occurs in some cosmetic formulations. The surfactant used in the study was sodium dodecyl sulfate (SDS), which is used in cosmetic formulations under its International Nomenclature of Cosmetic Ingredients (INCI) name Sodium Laurel Sulfate. In fish immobilization studies with Gambusia holbrooki, the EC(50) of the polyquaternium/surfactant complex was found to be the same as or similar to the EC(50) for the polyquaternium alone. The toxicity of the polyquaterniums investigated was similar to the published values for other cationic polyelectrolytes and cationic surfactants, in the range from < 1.0 to 10 mg/L, with the exception of low charge density cellulosic polyquaterniums. The anionic surfactant alone was not toxic to fish in the concentration range tested. Results thus showed the toxicity of the polyquaternium was not mitigated by the presence of the anionic surfactant.
Janet L Cumming; Darryl W Hawker; Kerry W Nugent; Heather F Chapman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering     Volume:  43     ISSN:  1093-4529     ISO Abbreviation:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-03     Completed Date:  2008-04-09     Revised Date:  2009-08-14    
Medline Journal Info:
Nlm Unique ID:  9812551     Medline TA:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
School of Environment, Griffith University, Nathan, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cosmetics / chemistry,  toxicity
Cyprinodontiformes / growth & development*
Electrolytes / toxicity*
Polymers / toxicity*
Quaternary Ammonium Compounds / toxicity*
Sodium Dodecyl Sulfate / toxicity
Surface-Active Agents / toxicity*
Reg. No./Substance:
0/Cosmetics; 0/Electrolytes; 0/Polymers; 0/Quaternary Ammonium Compounds; 0/Surface-Active Agents; 151-21-3/Sodium Dodecyl Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Continuing professional development in sensitive cultures.
Next Document:  Early neurotoxic effects of inhalation exposure to aluminum and/or manganese assessed by serum level...