| Economic evaluation of triflusal and aspirin in the treatment of acute myocardial infarction. | |
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MedLine Citation:
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PMID: 11929349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the costs to the Spanish healthcare system of 35 days' treatment with triflusal (600 mg/day) and aspirin (300 mg/day) in patients with confirmed acute myocardial infarction within 24 hours of onset of symptoms. DESIGN: A cost minimisation analysis based on the results of the Triflusal in Acute Myocardial Infarction study (TIM) was conducted. The hypothesis was that despite a higher acquisition cost of triflusal, savings would result because of differences in efficacy and safety outcome (non-fatal cerebrovascular event and haemorrhagic events). Diagnostic Related Groups were used as a proxy for determining hospital costs in Spain and the values were obtained from different sources and refer to year 2000 costs. Only direct medical costs were considered for the economic analysis. RESULTS: Although the acquisition cost of triflusal was more expensive than that of aspirin, the cost of prevented events - non-fatal ischaemic cerebrovascular events and cerebral haemorrhages - entirely compensated for the cost of triflusal. The overall cost of treating patients with triflusal, compared with aspirin, represented a net saving of 28.4% per patient treated. CONCLUSION: Our study showed that triflusal is cost saving compared with aspirin in the treatment of the acute phase of myocardial infarction. |
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Authors:
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Josep Darbà; Iñaki Izquierdo; Caridad Pontes; Carlos Navas; Joan Rovira |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: PharmacoEconomics Volume: 20 ISSN: 1170-7690 ISO Abbreviation: Pharmacoeconomics Publication Date: 2002 |
Date Detail:
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Created Date: 2002-04-03 Completed Date: 2002-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9212404 Medline TA: Pharmacoeconomics Country: New Zealand |
Other Details:
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Languages: eng Pagination: 195-201 Citation Subset: T |
Affiliation:
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Department of Economy, University of Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aspirin / economics*, therapeutic use* Double-Blind Method Drug Costs Humans Myocardial Infarction / drug therapy*, economics* Platelet Aggregation Inhibitors / economics*, therapeutic use* Recurrence Salicylates / economics*, therapeutic use* Spain |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 0/Salicylates; 322-79-2/triflusal; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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