| Ecology of Borrelia burgdorferi sensu lato in Europe: transmission dynamics in multi-host systems, influence of molecular processes and effects of climate change. | |
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MedLine Citation:
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PMID: 22091928 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The analysis of different multi-host systems suggests that even hosts that are not capable of transmitting Borrelia burgdorferi sensu lato (sl) to the tick vector, Ixodes ricinus, or that are secondary reservoirs for these agents contribute to the intensity of transmission and to the overall risk of Lyme borreliosis, through the process of vector augmentation and pathogen amplification. On the other hand, above certain threshold densities, or in the presence of competition with primary reservoir hosts or low attachment rate of ticks to reservoir hosts, incompetent or less competent hosts may reduce transmission through dilution. The transmission of B. burgdorferi sl is affected by molecular processes at the tick-host interface including mechanisms for the protection of spirochetes against the host's immune response. Molecular biology also increasingly provides important identification tools for the study of tick-borne disease agents. I. ricinus and B. burgdorferi sl are expanding their geographic range to northern latitudes and to higher altitudes through the effects of climate change on host populations, and on tick development, survival, and seasonal activity. The integration of quantitative ecology with molecular methodology is central to a better understanding of the factors that determine the main components of Lyme borreliosis eco-epidemiology, and should result in more accurate predictions of the effects of climate change on the circulation of pathogens in nature. |
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Authors:
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Alessandro Mannelli; Luigi Bertolotti; Lise Gern; Jeremy Gray |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-1 |
Journal Detail:
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Title: FEMS microbiology reviews Volume: - ISSN: 1574-6976 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902526 Medline TA: FEMS Microbiol Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
Affiliation:
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University of Torino, Grugliasco, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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