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Ecological risk assessment of endocrine disruptors.
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MedLine Citation:
PMID:  11102288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The European Centre for Ecotoxicology and Toxicology of Chemicals proposes a tiered approach for the ecological risk assessment of endocrine disruptors, integrating exposure and hazard (effects) characterization. Exposure assessment for endocrine disruptors should direct specific tests for wildlife species, placing hazard data into a risk assessment context. Supplementing the suite of mammalian screens now under Organization for Economic Cooperation and Development (OECD) validation, high priority should be given to developing a fish screening assay for detecting endocrine activity in oviparous species. Taking into account both exposure characterization and alerts from endocrine screening, higher tier tests are also a priority for defining adverse effects. We propose that in vivo mammalian and fish assays provide a comprehensive screening battery for diverse hormonal functions (including androgen, estrogen, and thyroid hormone), whereas Amphibia should be considered at higher tiers if there are exposure concerns. Higher tier endocrine-disruptor testing should include fish development and fish reproduction tests, whereas a full life-cycle test could be subsequently used to refine aquatic risk assessments when necessary. For avian risk assessment, the new OECD Japanese quail reproduction test guideline provides a valuable basis for developing a test to detecting endocrine-mediated reproductive effects; this species could be used, where necessary, for an avian life-cycle test. For aquatic and terrestrial invertebrates, data from existing developmental and reproductive tests remain of high value for ecological risk assessment. High priority should be given to research into comparative endocrine physiology of invertebrates to support data extrapolation to this diverse fauna.
Authors:
T H Hutchinson; R Brown; K E Brugger; P M Campbell; M Holt; R Länge; P McCahon; L J Tattersfield; R van Egmond
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  108     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1007-14     Citation Subset:  IM    
Affiliation:
AstraZeneca, Brixham Environmental Laboratory, Brixham, Devon, United Kingdom. tom.hutchinson@brixham.astrazeneca.com
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MeSH Terms
Descriptor/Qualifier:
Amphibians
Animals
Animals, Wild
Ecosystem
Endocrine Glands / drug effects*
Environmental Health
Environmental Monitoring / methods
Environmental Pollutants / toxicity*
Female
Fishes
Humans
Male
Mammals
Risk Assessment
Chemical
Reg. No./Substance:
0/Environmental Pollutants
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 11 Year: 2000
Volume: 108 Issue: 11
First Page: 1007 Last Page: 1014
ID: 1240154
PubMed Id: 11102288
Publisher Item Identifier: sc271_5_1835

Ecological risk assessment of endocrine disruptors.
T H Hutchinson
R Brown
K E Brugger
P M Campbell
M Holt
R L?nge
P McCahon
L J Tattersfield
R van Egmond
AstraZeneca, Brixham Environmental Laboratory, Brixham, Devon, United Kingdom. tom.hutchinson@brixham.astrazeneca.com


Article Categories:
  • Research Article


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