Document Detail


Ecological correlates of motor neuron disease mortality: a hypothesis concerning an epidemiological association with radon gas and gamma exposure.
MedLine Citation:
PMID:  8965106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigates variations in motor neuron disease (MND) mortality rates between the counties of England and Wales from 1981 to 1989, and their relationship with gamma-ray dose rates, indoor radon gas concentrations and enhanced general life expectancy. A strong correlation was confirmed between age-adjusted rates of MND mortality and life expectancy. Weaker, but statistically significant, associations were observed between indoor radon gas concentrations, terrestrial gamma radiation and marginal variations in MND mortality. Life expectancy and radon gas concentrations were positively associated with MND mortality rates whilst gamma radiation was negatively associated. The negative correlation of gamma radiation with MND mortality may be understood with reference to its negative effects on overall population life expectancy. Radon gas concentrations seemingly account for a small elevation in MND mortality, amounting to at most 4% of total deaths. Further research is required to investigate this association.
Authors:
S Neilson; I Robinson; F C Rose
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology     Volume:  243     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  329-36     Citation Subset:  IM    
Affiliation:
John Bevan MND Research Unit, Department of Human Sciences, University of West London, Uxbridge, Middlesex, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Dose-Response Relationship, Drug
Female
Gamma Rays
Humans
Male
Middle Aged
Motor Neuron Disease / epidemiology*,  mortality*
Radon / toxicity*
Sex Factors
Chemical
Reg. No./Substance:
10043-92-2/Radon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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