Document Detail

Ecological analysis of the relationship between infant mortality and cardiovascular disease mortality at ages 45-69 in the Brazilian 1935 birth cohort.
MedLine Citation:
PMID:  21514316     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: International ecological studies have shown a positive association between infant mortality as a proxy for low birth weight and cardiovascular disease mortality in adult life.
METHODS: Mortality rates due to Cardiovascular Diseases (CVDMR) standardised by age in adults between 45 and 69 years of age and by place of birth (pob) and residence (res) were related to Infant Mortality Rates (IMR) in the Brazilian 1935 birth cohort.
RESULTS: Two relationship patterns were noted between IMR and CVDMR: for the Southeast, South and Centre-West group of regions (r(pob)=0.46; r(res)=0.29) and for the North and Northeast group of regions (r(pob)=0.21; r(res)=0.33). For the latter pattern, two states were identified (Rio Grande do Norte and Paraíba) as atypical areas, whose exclusion strengthened the association (r(pob)=0.73; r(res)=0.91).
CONCLUSIONS: The direction of the associations changed after the analysis by group of Brazilian regions (indirect control of socio-economic levels, coverage and quality of the information). There is a positive, although weak association between IMR and CVDMR. Attempts to control or minimise the interference of migratory movements, cohort effects and socio-economic levels represented methodological progress in ecological analyses of foetal programming in Brazil.
Arthur Orlando Corrêa Schilithz; Cosme Marcelo Furtado Passos da Silva; Antonio Jose Leal Costa; Pauline Lorena Kale
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Publication Detail:
Type:  Journal Article     Date:  2011-04-15
Journal Detail:
Title:  Preventive medicine     Volume:  52     ISSN:  1096-0260     ISO Abbreviation:  Prev Med     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-09-30     Revised Date:  2012-05-08    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro (IESC/UFRJ), Praça Jorge Machado Moreira, Junto à Prefeitura Universitária UFRJ, Ilha do Fundão, Cidade Universitária, CEP: 21941-598, Rio de Janeiro, RJ, Brazil.
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MeSH Terms
Brazil / epidemiology
Cardiovascular Diseases / mortality*
Cause of Death*
Cluster Analysis
Cohort Studies
Ecology / methods
Infant Mortality*
Infant, Newborn
Residence Characteristics*
Socioeconomic Factors

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