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Echogenicity changes in the fetal brain, a six year follow-up study.
MedLine Citation:
PMID:  23356686     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective To asses the relation between echogenicity changes in the fetal brain and neurodevelopmental outcome until 6 years of age. Methods Fetuses (n=124) from pregnancies affected by hypertensive disorders (n=64) or preterm labor (n=60) at risk for preterm birth (26-34 weeks gestation) were studied. Moderate echogenicity changes (periventricular grade IB, II; intraventricular grade II-III; local basal ganglia/thalami) in the fetal and neonatal brain were related to neurological outcome and Griffiths mental developmental scales quotients at 1, 2 and 6 years. Multiple regression analysis tested the influence of moderate echogenicity changes and perinatal clinical characteristics on composite outcome (death or abnormal neurodevelopment). Results Moderate echogenicity changes were present in 37/124 (30%) fetuses. Median gestational age and weight at birth were respectively 31 weeks (range 26-43), and 1314g (range 550-4330), mortality was 19%, follow-up loss 10%. Composite outcome was abnormal in 47/124 (38%). Fetal and neonatal moderate intraventricular echodensities were related to cerebral palsy at 6 year (p<0.04). In the multiple regression analysis only gestational age was related to composite outcome (p= 0.005). Conclusions Moderate intraventricular echodensities in the fetal brain related to cerebral palsy at 6 years of age. Gestational age at birth was the main predictor of abnormal composite outcome.
Authors:
Dunné F M F Rosier-van; G van Wezel-Meijler; L de Groot; J I van Zyl; H J Odendaal; J I P de Vries
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-29
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Research Institute MOVE, VU University Medical Centre, Amsterdam, the Netherlands.
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