| Echogenic liposomes for vasoactive gas delivery and inhibition of intima hyperplasia in atheroproliferative disease. | |
| | |
MedLine Citation:
|
PMID: 18530149 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Our group has developed targeted echogenic liposomes (ELIP) for targeted ultrasound enhancement of atheroma as well as targeted therapeutic delivery. Nitric oxide (NO) has potent biological activities but is too labile for in-vivo vascular delivery. We have developed a methodology to entrap NO, cause local prolonged release and retain NO effect. NO-loaded ELIP were injected into the common carotid artery after balloon injury. Fourteen days later, the carotids were removed. Administration of NO-ELIP resulted in 51+/-6% inhibition of intimal thickening when compared with controls. Using a 6.0 MHz clinical Doppler diagnostic ultrasound system, we (Smith et al) have identified the optimal pressure threshold (MI 0.08) for NO diffusion from ELIP. Using these parameters we have enhanced vascular permeability of drugs and stem cells to help stabilize atherosclerotic plaques. We have developed a novel method for encapsulating NO into ELIP demonstrating their capacity for NO delivery, inhibition of intimal hyperplasia and controlled gas diffusion with ultrasound. This methodology provides a new approach for delivering a variety of bioactive gases to target tissues, which otherwise would have negligible effects when administered systemically. |
| | |
Authors:
|
Huang Shaoling Huang; David D McPherson; Christy K Holland |
Related Documents
:
|
7318319 - Blood volume and the carotid baroreceptor reflex in conscious rabbits. 2409389 - Reflex cardiovascular regulation in humans. 104549 - Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensiv... 21715069 - Litterfall mercury dry deposition in the eastern usa. 21641509 - Pressure ulcers in long-term care. 17622209 - Good correlation between cerebral oxygenation measured using near infrared spectroscopy... 23215319 - Pressure-induced heavy fermion superconductivity in the nonmagnetic quadrupolar system ... 20673339 - Control of positive end-expiratory pressure (peep) for small animal ventilators. 9878309 - Twenty-four-hour heart preservation using continuous cold perfusion and copper (ii) com... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of the Acoustical Society of America Volume: 123 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-06-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
|
Languages: eng Pagination: 3216 Citation Subset: IM |
Affiliation:
|
MSB 1.246, 6431 Fannin St., Houston, TX 77030, USA, Shaoling.Huang@uth.tmc.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Echogenic liposomes for molecular targeted therapeutic delivery.
Next Document: Characterization and Optimization of Ultrasound-induced Molecular Delivery In Vivo.