Document Detail

Echogenic liposomes for vasoactive gas delivery and inhibition of intima hyperplasia in atheroproliferative disease.
MedLine Citation:
PMID:  18530149     Owner:  NLM     Status:  In-Data-Review    
Our group has developed targeted echogenic liposomes (ELIP) for targeted ultrasound enhancement of atheroma as well as targeted therapeutic delivery. Nitric oxide (NO) has potent biological activities but is too labile for in-vivo vascular delivery. We have developed a methodology to entrap NO, cause local prolonged release and retain NO effect. NO-loaded ELIP were injected into the common carotid artery after balloon injury. Fourteen days later, the carotids were removed. Administration of NO-ELIP resulted in 51+/-6% inhibition of intimal thickening when compared with controls. Using a 6.0 MHz clinical Doppler diagnostic ultrasound system, we (Smith et al) have identified the optimal pressure threshold (MI 0.08) for NO diffusion from ELIP. Using these parameters we have enhanced vascular permeability of drugs and stem cells to help stabilize atherosclerotic plaques. We have developed a novel method for encapsulating NO into ELIP demonstrating their capacity for NO delivery, inhibition of intimal hyperplasia and controlled gas diffusion with ultrasound. This methodology provides a new approach for delivering a variety of bioactive gases to target tissues, which otherwise would have negligible effects when administered systemically.
Huang Shaoling Huang; David D McPherson; Christy K Holland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  123     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3216     Citation Subset:  IM    
MSB 1.246, 6431 Fannin St., Houston, TX 77030, USA,
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