Document Detail


Echogenic liposomes for molecular targeted therapeutic delivery.
MedLine Citation:
PMID:  18530148     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Our group has developed targeted echogenic liposomes (ELIP) that can entrap therapeutics and release them at the target site. A key therapeutic is t-PA (tissue plasminogen activator). We have demonstrated entrapment and release following ultrasound application with t-PA effect on clot dissolution. We have demonstrated that t-PA can act as a targeting agent. Thus this drug can be both a targeting agent and a lytic agent minimizing the development of complicated formulations required for targeting and lysis. We have entrapped glitazones and demonstrated release following ultrasound application with drug effect by suppressing vascular hyperplasia. We have demonstrated that ultrasound with our ELIP can enhance delivery of agents into all areas of the atheroma, including the intima, media, the loose and dense adventitia. Heretofore these regions close to the arterial media have been impenetrable using standard intravenous drug therapy. These projects are helping to develop our echogenic immunoliposomes to; optimize targeted contrast delivery into vascular beds that are poorly penetrable by standard imaging agents; and optimize local release and concentration of therapeutics at the site of interest. This will ultimately help to direct therapeutic delivery, increase local effect, while minimizing the systemic effects of drugs and genes.
Authors:
David D McPherson; Shaoling Huang; Christy K Holland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  123     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3216     Citation Subset:  IM    
Affiliation:
University of Texas Health Science Center, 6431 Fannin St., MSB 1.252, Houston, TX 77030, USA, David.D.McPherson@uth.tmc.edu.
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