| Echocardiography in thalassemic patients on blood transfusions and chelation without heart failure. | |
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MedLine Citation:
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PMID: 23295250 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Patients with thalassemia major present chronic hemolysis and require regular blood transfusions which may cause iron overload cardiomyopathy and chronic heart failure. Hemochromatosis is characterized by excessive iron accumulation in tissues, and heart involvement is the main cause of death in patients with thalassemia. OBJECTIVE: The aim of this study was to evaluate cardiac structure and function by conventional Doppler echocardiography and tissue Doppler imaging in patients with TM and no clinical evidence of heart failure. METHODS: This is a prospective observational study including 18 patients with thalassemia major (TM) receiving regular blood transfusion. To separately evaluate anemia and blood transfusion effects, two gender, age, weight, and height-matched control groups were included: one with healthy individuals (Healthy, n=18) and one with iron deficient anemia patients (Anemia, n=18). Statistical analysis was performed using ANOVA followed by Tukey's test or Kruskal-Wallis's and Dunn's test. RESULTS: The following echocardiographic variables presented significantly higher values in TM than the Anemia and Healthy groups: left atrium volume index (Healthy: 16.4±6.08; Anemia: 17.9±7.02; TM: 24.1±8.30 cm³/m²); mitral septal E/Em ratio (Healthy: 6.55±1.60; Anemia: 6.74±0.74; TM: 8.10±1.31); and duration of reverse pulmonary vein flow [Healthy: 74.0 (59.0-74.0); Anemia: 70.5 (67.0-74.0); TM: 111 (87.0-120) ms]. The mitral E/A ratio was higher in TM than Anemia (Healthy: 1.80±0.40; Anemia: 1.80±0.24; TM: 2.03±0.34). No differences were found in left ventricular structures and systolic function indexes. CONCLUSION: Conventional Doppler echocardiography and tissue Doppler allow changes in left ventricular diastolic function to be identified in asymptomatic patients with thalassemia major. |
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Authors:
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Alexandre Rodrigues; Fábio Villaça Guimarães-Filho; João Carlos Ferreira Braga; Cássia Spínola Custódio Rodrigues; Paulo Waib; Antonio Fabron-Junior; Doralice Marvulle Tan; Ana Cristina C V França; Marina Politi Okoshi; Katashi Okoshi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-08 |
Journal Detail:
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Title: Arquivos brasileiros de cardiologia Volume: - ISSN: 1678-4170 ISO Abbreviation: Arq. Bras. Cardiol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: - |
Other Details:
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Languages: ENG; POR Pagination: - Citation Subset: - |
Affiliation:
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Departamento de Clínica Médica, Faculdade de Medicina de Marília. |
Vernacular Title:
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Ecocardiografia de pacientes talassêmicos sem insuficiência cardíaca em tratamento com transfusões sanguíneas e quelação. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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