Document Detail

Echocardiography-derived variables predict outcome in patients with nonischemic dilated cardiomyopathy with or without a restrictive filling pattern.
MedLine Citation:
PMID:  12177655     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite recent therapeutic advances, patients with heart failure caused by dilated cardiomyopathy (DCM) still have high morbidity and mortality rates. In this study, we sought to assess the prognostic value of echocardiographic variables in patients with DCM and to assess the impact of a restrictive left ventricle filling pattern. DESIGN: We conducted a retrospective cohort study of 337 patients with DCM, using the Royal Brompton Hospital Echocardiography database for the years 1994 to 1998. METHODS AND RESULTS: There were 337 patients with a mean age of 53 +/- 15 years. One hundred ninety-five patients (58%) had a restrictive left ventricle filling pattern (RFP). There was a total of 74 deaths (22%) during the follow-up period (43 +/- 25 months). RFP more than tripled the risk of death (adjusted hazard ratio 3.2, 95% CI 1.8-5.7, P =.003). RFP is correlated with isovolumic relaxation time, incoordinate wall-motion, amplitude of right ventricular long axis excursion on M-mode echocardiography, and mitral regurgitation. CONCLUSION: RFP is a powerful independent predictor of mortality in patients with nonischemic DCM. The risk associated with RFP is greatest among patients who had short isovolumic relaxation time, mitral regurgitation, incoordinate wall-motion, and depressed amplitude of right ventricular long axis excursion. Thus, echocardiography-derived variables may stratify patients with heart failure with DCM who are at high risk, for whom aggressive medical treatment or heart transplantation should be considered early.
Rajaa Faris; Andrew J S Coats; Michael Y Henein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  144     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-14     Completed Date:  2002-09-04     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  AIM; IM    
Department of Clinical Cardiology, National Heart and Lung Institute, The Royal Brompton Hospital, Imperial College School of Science, Technology, and Medicine, London, United Kingdom.
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MeSH Terms
Aged, 80 and over
Cardiomyopathy, Dilated / mortality*,  ultrasonography*
Cohort Studies
Echocardiography / methods*
Follow-Up Studies
Middle Aged
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Survival Rate
Ventricular Dysfunction, Left / epidemiology

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