Document Detail

Echocardiography at diagnosis of antiphospholipid syndrome provides prognostic information on valvular disease evolution and identifies two subtypes of patients.
MedLine Citation:
PMID:  20068017     Owner:  NLM     Status:  MEDLINE    
The evolution of valvular disease in antiphospholipid syndrome (APS) is barely known. In order to evaluate whether the presence or absence of valvular disease at the time of diagnosis of APS, assessed by an initial echocardiogram, predicts its subsequent evolution, we performed a prospective cohort study. We included 53 patients with APS. An initial transthoracic echocardiogram was performed on patients at the time of diagnosis of APS. Serial echocardiograms were conducted along a 12-year follow-up. Final echocardiograms were used for comparative purposes. We started with 29 patients (54%) with and 24 (45%) without valvulopathy at initial echo. At the final echocardiogram, 27 of 29 patients with initial valvulopathy continued to have valvular disease (a 93% observed likelihood), and 22 of 24 patients without initial valvulopathy demonstrated an absence of valvular disease (a 91% observed likelihood). Patients with valvulopathy in comparison with those without presented more arterial thrombotic events (69% vs. 20%, P < 0.001), atherosclerotic risk factors (62% vs. 29%, P = 0.01), livedo (48% vs. 16%, P = 0.01) and migraine (41% vs. 12%, P = 0.02). We have identified two subtypes of APS patients with and without valvulopathy by defining differential clinical features and with little crossover in valvular involvement over a long follow-up period, giving a high prognostic value to the initial echocardiographic assessment.
J Pardos-Gea; J Ordi-Ros; G Avegliano; J Cortés-Hernández; E Balada; A Evangelista; M Vilardell
Related Documents :
3455547 - The heart in rheumatoid arthritis--a clinical and echocardiographic study.
18222637 - The incidence and clinical course of caseous calcification of the mitral annulus: a pro...
9741517 - Mechanisms of hemolysis after mitral valve repair: assessment by serial echocardiography.
2237767 - Traumatic disruptions of the thoracic aorta: treatment and outcome.
6825987 - An unusually high incidence of gastrointestinal obstruction by persimmon bezoars in isr...
19758197 - Human leukocyte antigen-drb1 and -dqb1 genotyping in lupus patients with and without an...
Publication Detail:
Type:  Journal Article     Date:  2010-01-12
Journal Detail:
Title:  Lupus     Volume:  19     ISSN:  1477-0962     ISO Abbreviation:  Lupus     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-08-16     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  575-82     Citation Subset:  IM    
Department of Internal Medicine, Autoimmune Diseases Unit, Hospital Universitari Vall d'Hebron, Universitat Autónoma de Barcelona, Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antiphospholipid Syndrome / classification*,  complications*
Follow-Up Studies
Heart Valve Diseases / etiology*,  ultrasonography*
Prospective Studies
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Practice pattern variation in oral glucocorticoid therapy after the induction of response in prolife...
Next Document:  Lupus-prone New Zealand Black/New Zealand White F1 mice display endothelial dysfunction and abnormal...