| Echocardiographic screening for congenital heart disease: a randomized study. | |
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MedLine Citation:
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PMID: 12235719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the effectiveness and potential cost of an echocardiographic screening program for congenital heart disease (CHD). PATIENTS AND METHODS: Between 01/11/94 and 28/02/98 there were 9697 deliveries in The Royal Maternity Hospital Belfast. Mothers were randomized before delivery. 4875 infants were allocated to the scan group, while 4822 were assigned to clinical assessment alone. High-risk infants were considered separately. Cases of CHD detected before hospital discharge were documented. The annual cost of screening was estimated and the time to accurate diagnosis in each group was assessed. RESULTS: During the study 124 scan allocated infants and 50 controls were identified as having significant CHD before hospital discharge. With a minimum of 3 years follow-up there were 27 additional late diagnoses in controls and 1 in scanned infants. During a single year of the study the mean time to complete diagnosis was 2 days for scanned cases and 110 in controls. The projected cost of screening for all infants was 22 Pounds/infant for the first year. CONCLUSIONS: Adding echocardiography to clinical examination greatly enhances early detection of CHD. Although screening is expensive, once established it may reduce the cost of unnecessary outpatient referrals. |
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Authors:
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Andrew Sands; Brian Craig; Connor Mulholland; Christopher Patterson; James Dornan; Frank Casey |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 30 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2002 |
Date Detail:
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Created Date: 2002-09-18 Completed Date: 2003-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 307-12 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Royal Hospitals, Belfast, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cost-Benefit Analysis Echocardiography* / economics, methods Female Heart Defects, Congenital / epidemiology, ultrasonography* Humans Infant, Newborn Northern Ireland / epidemiology Population Surveillance / methods Pregnancy Prospective Studies Ultrasonography, Prenatal* / economics, methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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