Document Detail

Echocardiographic predictors of symptomatic patent ductus arteriosus in extremely-low-birth-weight preterm neonates.
MedLine Citation:
PMID:  20182434     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Identify echocardiographic parameters at <or=4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW).
STUDY DESIGN: Serial echocardiograms obtained in 115 ELBW at <or=10 day postnatal were examined to estimate PDA size using the PDA:left pulmonary artery (LPA) diameter ratio: >or=1 indicated a large PDA, <1 but >or=0.5 moderate, and <0.5 small. Sensitivity, specificity, and positive predictive values (PPV) were determined for ELBW <27 weeks and >or=27 weeks gestational age.
RESULT: Neonates with moderate to large PDA at <or=4 day had 15-times greater likelihood of requiring treatment for sPDA than those with a small PDA (95% confidence interval (CI): 5.6-41). Sensitivity, specificity and PPV of the PDA:LPA at <27 weeks was 80, 86 and 92%, respectively.
CONCLUSION: A moderate to large PDA determined from the PDA:LPA ratio at <or=4 day postnatal identifies neonates <27 week gestation who subsequently require closure of a PDA.
F G Ramos; C R Rosenfeld; L Roy; J Koch; C Ramaciotti
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Publication Detail:
Type:  Journal Article     Date:  2010-02-25
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  535-9     Citation Subset:  IM    
Division of Cardiology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Ductus Arteriosus, Patent / classification,  ultrasonography*
Gestational Age
Infant, Extremely Low Birth Weight*
Infant, Newborn
Predictive Value of Tests
Regional Blood Flow
Retrospective Studies
Severity of Illness Index*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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