Document Detail

Echocardiographic evaluation of systolic and mean pulmonary artery pressure in the follow-up of patients with pulmonary hypertension.
MedLine Citation:
PMID:  21821609     Owner:  NLM     Status:  MEDLINE    
AIMS: To identify a correction of the modified Bernoulli formula used to estimate systolic and mean pulmonary artery pressure [sPAP and mPAP; respectively: sPAP = 4 × TRv (tricuspid regurgitation velocity)(2)+ RAP (right atrial pressure); and mPAP = 0.61sPAP + 2], applicable in the follow-up of pulmonary hypertension (PH) patients.
METHODS AND RESULTS: From January 1979 to December 2009, 60 patients with precapillary (class I and IV) and 'out of proportion' PH were consecutively enrolled in the PH Registry of Trieste. All patients underwent both echocardiographic and right heart catheter evaluation. We used a simple-linear-regression method in order to compare sPAP and mPAP Doppler-estimated values with the respective right-heart catheterization invasive variables. The comparison of the estimated with the traditional modified Bernoulli formula echo-Doppler data and the effective invasive values confirmed a significant association between them (for sPAP P< 0.001; for mPAP P= 0.006). Simple-linear-regression-derived formulas were sPAP = 1.07 × (4TRv(2)+ RAP) + 7.4 (1) and mPAP = 1.1 × (0.61sPAP + 2) + 2.5 (2). These regression-corrected formulas were validated in an external population of PH patients.
CONCLUSION: Our data suggest that formulas (1) and (2) could be more reliable with respect to the traditional modified Bernoulli equation, when estimating echocardiographically sPAP and mPAP in patients with PH confirmed by right-heart catheterization.
Stylianos A Pyxaras; Bruno Pinamonti; Giulia Barbati; Sara Santangelo; Matej Valentincic; Francesca Cettolo; Gabriele Secoli; Silvia Magnani; Marco Merlo; Francesco Lo Giudice; Andrea Perkan; Gianfranco Sinagra
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Publication Detail:
Type:  Journal Article     Date:  2011-08-04
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  12     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-13     Completed Date:  2012-01-18     Revised Date:  2012-01-24    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-701     Citation Subset:  IM    
Cardiovascular Department, Pulmonary Hypertension Division, University Hospital of Trieste, Via Valdoni 7, 34149, Trieste, Italy.
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MeSH Terms
Blood Pressure
Blood Pressure Determination / methods*
Echocardiography, Doppler*
Heart Catheterization
Hypertension, Pulmonary / physiopathology*,  ultrasonography
Middle Aged
Predictive Value of Tests
Pulmonary Artery / physiology*
Sensitivity and Specificity
Comment In:
Eur J Echocardiogr. 2011 Dec;12(12):969; author reply 968   [PMID:  22109248 ]

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