| Echocardiographic evaluation of patients with primary antiphospholipid syndrome. | |
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MedLine Citation:
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PMID: 10220649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A third to half of the patients with primary antiphospholipid syndrome have valve disease. METHODS AND RESULTS: The echocardiographic characteristics of primary antiphospholipid syndrome were analyzed, and the utility of treatment with anticoagulants and/or antiplatelet agents (acetylsalicylic acid) is examined with the use of transesophageal echocardiography in the evaluation of valvular lesions after 1 year of therapy. Twenty-nine patients, 22 women and 7 men with average age of 35.4 years, were studied. Transesophageal echocardiography was performed on all patients before beginning anticoagulant and/or antiplatelet treatment. Valve lesions were found in 22 (75.9%) patients. Of these, other cardiac abnormalities were found in 3 cases, myocardial infarction in 2, and atrial septal defect in 1. In 7 (24.1%) cases, no valvular abnormality was detected, although in 1 of these, alterations in left ventricular segmental wall movement secondary to myocardial infarction were found. One year after initiation of anticoagulant and/or antiplatelet therapy, it was possible to perform transesophageal echocardiograms on 13 patients. No modification of valve lesions was found in 6 (46.2%) cases; new lesions had appeared in the remaining 7 (53.8%) as well as left ventricular apical akinesis in 1 case. CONCLUSIONS: These results indicate that the predominant heart lesion in primary antiphospholipid syndrome is valvular; anticoagulant and/or antiplatelet treatment does not diminish the noninfective valve lesions, and on occasion this entity may be associated with myocardial infarction despite angiographically normal coronary arteries. |
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Authors:
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N Espínola-Zavaleta; J Vargas-Barrón; T Colmenares-Galvis; F Cruz-Cruz; A Romero-Cárdenas; C Keirns; M C Amigo |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 137 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-06-04 Completed Date: 1999-06-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 973-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Echocardiography, Instituto Nacional de Cardiología "Ignacio Chávez.", Mexico City, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anticoagulants / therapeutic use Antiphospholipid Syndrome / complications, drug therapy, ultrasonography* Diagnosis, Differential Drug Therapy, Combination Echocardiography, Transesophageal* Female Follow-Up Studies Heart Valve Diseases / etiology, ultrasonography Humans Male Middle Aged Platelet Aggregation Inhibitors / therapeutic use Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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