Document Detail

Echocardiographic evaluation of patients with primary antiphospholipid syndrome.
MedLine Citation:
PMID:  10220649     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A third to half of the patients with primary antiphospholipid syndrome have valve disease. METHODS AND RESULTS: The echocardiographic characteristics of primary antiphospholipid syndrome were analyzed, and the utility of treatment with anticoagulants and/or antiplatelet agents (acetylsalicylic acid) is examined with the use of transesophageal echocardiography in the evaluation of valvular lesions after 1 year of therapy. Twenty-nine patients, 22 women and 7 men with average age of 35.4 years, were studied. Transesophageal echocardiography was performed on all patients before beginning anticoagulant and/or antiplatelet treatment. Valve lesions were found in 22 (75.9%) patients. Of these, other cardiac abnormalities were found in 3 cases, myocardial infarction in 2, and atrial septal defect in 1. In 7 (24.1%) cases, no valvular abnormality was detected, although in 1 of these, alterations in left ventricular segmental wall movement secondary to myocardial infarction were found. One year after initiation of anticoagulant and/or antiplatelet therapy, it was possible to perform transesophageal echocardiograms on 13 patients. No modification of valve lesions was found in 6 (46.2%) cases; new lesions had appeared in the remaining 7 (53.8%) as well as left ventricular apical akinesis in 1 case. CONCLUSIONS: These results indicate that the predominant heart lesion in primary antiphospholipid syndrome is valvular; anticoagulant and/or antiplatelet treatment does not diminish the noninfective valve lesions, and on occasion this entity may be associated with myocardial infarction despite angiographically normal coronary arteries.
N Espínola-Zavaleta; J Vargas-Barrón; T Colmenares-Galvis; F Cruz-Cruz; A Romero-Cárdenas; C Keirns; M C Amigo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  137     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-04     Completed Date:  1999-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  973-8     Citation Subset:  AIM; IM    
Department of Echocardiography, Instituto Nacional de Cardiología "Ignacio Chávez.", Mexico City, Mexico.
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MeSH Terms
Anticoagulants / therapeutic use
Antiphospholipid Syndrome / complications,  drug therapy,  ultrasonography*
Diagnosis, Differential
Drug Therapy, Combination
Echocardiography, Transesophageal*
Follow-Up Studies
Heart Valve Diseases / etiology,  ultrasonography
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use
Retrospective Studies
Reg. No./Substance:
0/Anticoagulants; 0/Platelet Aggregation Inhibitors

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