Document Detail

Echocardiographic evaluation including tissue Doppler imaging in New Zealand white rabbits sedated with ketamine and midazolam.
MedLine Citation:
PMID:  18445537     Owner:  NLM     Status:  MEDLINE    
Limited data are available on the use of more recent echocardiographic parameters in the rabbit. Echocardiographic examination, including conventional echocardiography and tissue Doppler imaging (TDI), was performed on 26 male New Zealand white rabbits under ketamine-midazolam sedation. Particular emphasis was placed on the more recent systolic and diastolic parameters, such as myocardial performance index (Tei index) and mitral annular motion (from septal and lateral sides of the left ventricle) obtained using pulsed TDI. Parameters that assessed systolic and diastolic function (fractional shortening, Tei index, and maximal mitral E- and A-wave velocities) were comparable to those reported in the literature for rabbits in the awake state. The less cardiodepressive anaesthetic protocol could offer a good alternative in performing echocardiographic evaluation whenever such caution is necessary. TDI is feasible in healthy rabbits and potentially suitable for the investigation of left ventricle systolic and diastolic function.
Ana Patrícia Fontes-Sousa; Cláudia Moura; Catarina Santos Carneiro; Armando Teixeira-Pinto; José Carlos Areias; Adelino F Leite-Moreira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-28
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  181     ISSN:  1090-0233     ISO Abbreviation:  Vet. J.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  326-31     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
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MeSH Terms
Echocardiography, Doppler / veterinary*
Heart / physiology*
Hypnotics and Sedatives / pharmacology*
Ketamine / pharmacology*
Midazolam / pharmacology*
Rabbits / physiology*
Reg. No./Substance:
0/Hypnotics and Sedatives; 59467-70-8/Midazolam; 6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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