Document Detail

Echocardiographic evaluation of cardiac abnormalities in Duchenne's dystrophy and myotonic muscular dystrophy.
MedLine Citation:
PMID:  7387444     Owner:  NLM     Status:  MEDLINE    
Routine echocardiographic examinations were performed on 53 individuals with muscular dystrophy (29 with myotonic muscular dystrophy [MMD] and 24 with Duchenne's dystrophy [DD]). Five of 29 (17%) with MMD and six of 24 (25%) with DD had typical mitral valve prolapse evidenced by echocardiography. All patients with DD and mitral valve prolapse had severe thoracic skeletal deformities, while none with MMD and mitral valve prolapse had such abnormalities. Other echocardiographic parameters analyzed included the fractional shortening of the left ventricle (% delta S), excursions of the left ventricular posterior wall (LVPW) and the ventricular septum, pre-ejection period/left ventricular ejection time ratios (PEP/LVET), and thickness of the LVPW and ventricular septum. Abnormal prolongation of the PEP/LVET ratio and increased thicknesses of the LVPW and ventricular septum were noted in some individuals in the MMD group. Decreased % delta S with diminished excursion and diastolic velocity of the LVPW were noted in some with DD.
W C Reeves; R Griggs; N C Nanda; K Thomson; R Gramiak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  37     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-08-15     Completed Date:  1980-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Heart Diseases / physiopathology*
Heart Septum / physiopathology
Heart Ventricles / physiopathology
Middle Aged
Mitral Valve Insufficiency / physiopathology
Mitral Valve Prolapse / physiopathology
Muscular Dystrophies / physiopathology*
Myotonic Dystrophy / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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