| Echocardiographic and electrocardiographic analyses of patients with severe motor and intellectual disabilities. | |
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MedLine Citation:
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PMID: 19165569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe motor and intellectual disabilities (SMID) syndrome is a heterogeneous group of disorders with severe physical disabilities and mental retardation. Higher incidence of sudden death is also known in these patients. However, little is known about the cardiovascular features of patients with SMID. We examine the patients with severe motor and intellectual disabilities using echocardiogram and clarify their characterization of ventricular function. We performed electrocardiographic and echocardiographic analyses in SMID patients. In all patients, two-dimensional echocardiography with tissue Doppler analysis in the pulsed Doppler mode was performed. Of 121 patients, 104 patients had abnormal findings: 81 had poor R-wave progression, and 15 patients had low-voltage QRS on ECG. These findings strongly correlated with the degree of physical disability. However, on echocardiography, most patients had LVEF in the normal range, while LV Tei indices were significantly higher (0.43 vs 0.31 cm/s) and left ventricular end-diastolic dimension significantly smaller than healthy controls (P<0.05 for each comparison). Patients had significantly decreased early diastolic tissue Doppler velocities at the lateral mitral (5.3 vs 6.7 cm/s), tricuspid (6.7 vs 9.2 cm/s), and septal (5.9 vs 8.8 cm/s) annuli compared with controls (P<0.05 for each comparison). We show for the first time that SMID patients have low E/Ea ratios on tissue Doppler imaging while LV contractions are normal, suggesting the existence of latent diastolic dysfunction. This may be one of the reasons why the incidence of sudden death is higher in SMID patients. |
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Authors:
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Keiichi Hirono; Tohru Konishi; Hideki Origasa; Fukiko Ichida; Toshio Miyawaki |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-01-23 |
Journal Detail:
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Title: Heart and vessels Volume: 24 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 46-53 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Faculty of Medicine, University of Toyama, 2630 Sugitani, 930-0194 Toyama, Japan. khirono-circ@umin.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Child, Preschool Disability Evaluation* Echocardiography, Doppler / methods* Electrocardiography / methods* Female Follow-Up Studies Humans Infant Male Mental Retardation / complications, rehabilitation* Middle Aged Myotonia / complications, rehabilitation* Prognosis Retrospective Studies Stroke Volume / physiology Ventricular Dysfunction / complications, diagnosis*, rehabilitation Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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