Document Detail

Echocardiographic detection of mitral valve prolapse. Exclusion of false positive diagnosis and determination of inheritance.
MedLine Citation:
PMID:  1182954     Owner:  NLM     Status:  MEDLINE    
An important potential source of error in the echocardiographic diagnosis of mitral valve prolapse has been identified -- namely a systolic hammock-like pattern of the anterior and/or posterior mitral leaflet echoes, similar to that associated with true mitral valve prolapse, produced artifactually when the ultrasonic transducer is angulated inferiorly. Utilizing a modified, more specific technique we characterized the mode of inheritance and familial prevalence of this disorder. Among 74 subjects, composed of 57 first-degree relatives and 17 propositi with mitral valve prolapse, mitral valve prolapse was detected in 27 of 57 (47%) of the first-degree relatives. Fifty-three percent of female and 36% of male progeny of propositi were affected. Furthermore, familial transmission occurred from propositi to both sexes. Results of this study indicate that mitral valve prolapse is transmitted in an autosomal dominant mode with reduced male expressivity and a familial prevalence of 47% and that appropriate echocardiographic techniques must be employed to avoid a high incidence of false positive diagnosis.
A N Weiss; J W Mimbs; P A Ludbrook; B E Sobel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  52     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-01-30     Completed Date:  1976-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1091-6     Citation Subset:  AIM; IM    
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MeSH Terms
Diagnosis, Differential
Echocardiography / methods*
False Positive Reactions
Genes, Dominant
Middle Aged
Mitral Valve Insufficiency / diagnosis*,  genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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