Document Detail


Echocardiographic assessment of left ventricular geometry and the mitral valve apparatus in cats with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  20185379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This retrospective study addressed the general hypothesis that abnormalities of the mitral valve apparatus are common in cats with idiopathic hypertrophic cardiomyopathy (HCM) and contribute to dynamic obstruction of the left ventricular outflow tract (LVOT). ANIMALS, MATERIALS AND METHODS: 106 cats (28 controls and 78 with HCM) had transthoracic two-dimensional and Doppler echocardiography performed with quantification of 33 variables. Three groups of cats (control [Group-1], HCM without obstruction [Group-2], and HCM with obstruction [Group-3]) were identified and compared by analysis of variance, chi(2) analysis, and correlation analysis. RESULTS: Cats in Group-3 had more LV and papillary muscle hypertrophy, increased length of the anterior mitral valve leaflet, and a higher prevalence of false tendons in the LVOT compared to cats in Group-2 (P < or = 0.05). The length of the anterior mitral valve leaflet was correlated to the severity of dynamic obstruction (P < or = 0.05) and the magnitude of LV hypertrophy (P < or = 0.001). Systolic anterior motion of chordae tendineae (CAM) was observed in 16% of control cats and >50% of cats with HCM (P < or = 0.05). CONCLUSIONS: Abnormalities of the mitral valve are common in cats with HCM suggesting a possible role in the pathogenesis of dynamic outflow tract obstruction.
Authors:
Karsten Schober; Amanda Todd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-24
Journal Detail:
Title:  Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology     Volume:  12     ISSN:  1875-0834     ISO Abbreviation:  J Vet Cardiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101163270     Medline TA:  J Vet Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-16     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L Tharp Street, Columbus, OH 43210, USA. schober.4@osu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathy, Hypertrophic / ultrasonography,  veterinary*
Case-Control Studies
Cat Diseases / ultrasonography*
Cats
Echocardiography / veterinary
Echocardiography, Doppler / veterinary
Female
Heart Murmurs / veterinary
Heart Ventricles / ultrasonography*
Male
Mitral Valve / ultrasonography*
Mitral Valve Insufficiency / ultrasonography,  veterinary
Ventricular Outflow Obstruction / ultrasonography,  veterinary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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