Document Detail


Echocardiographic analysis with a two-dimensional strain of chronic myocardial ischemia induced with ameroid constrictor in the pig.
MedLine Citation:
PMID:  20139196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite much progress in the medical management of myocardial ischemia, several problems remain and experimental models help to improve our understanding of the pathophysiology involved in this domain. The ameroid constrictor model is the most widely used to create ischemia but evaluation of patent ischemia is still under debate. In the present study, we describe the potential of a two-dimensional (2D) strain for experimentally evaluating myocardial ischemia in the pig. An ameroid constrictor was placed around the circumflex artery in 30 pigs. Angiography showed 90% stenosis at one and two months. Left ventricular function was moderately altered and associated with mitral valve insufficiency in 30% of cases. Longitudinal and circumference strains were dramatically modified in the ischemic inferior-lateral zone compared to the healthy anterior zone (P<0.01) at one and two months. We correlated these results to myocardial ischemia by using contrast echocardiography, which showed a significant reduction in myocardial perfusion in the ischemic zone compared to the uninjured area, and by using histological analysis. We showed that evaluation of the 2D strain could be an interesting approach for assessing myocardial ischemia after ameroid constrictor implantation. The 2D strain represents a useful tool for the evaluation of experimental models of myocardial ischemia.
Authors:
Dominique Caillaud; Joachim Calderon; Patricia Réant; Stéphane Lafitte; Pierre Dos Santos; Thierry Couffinhal; Xavier Roques; Laurent Barandon
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-02-05
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  10     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  689-93     Citation Subset:  IM    
Copyright Information:
2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
Affiliation:
Inserm U 828, Avenue du Haut-Lévêque, 33600 Pessac, France.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Biopsy, Needle
Caseins
Chronic Disease
Coronary Angiography / methods
Coronary Stenosis / complications,  pathology*,  radiography,  surgery
Disease Models, Animal
Echocardiography / methods*
Hydrogels
Immunohistochemistry
Male
Myocardial Ischemia / etiology,  pathology*,  surgery,  ultrasonography*
Random Allocation
Swine
Ventricular Function, Left / physiology
Chemical
Reg. No./Substance:
0/Caseins; 0/Hydrogels; 9005-93-0/ameroid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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