Document Detail

Echocardiographic analysis of human left ventricular diastolic volume and cardiac performance during halothane anesthesia.
MedLine Citation:
PMID:  571218     Owner:  NLM     Status:  MEDLINE    
Using M-mode echocardiography we found that 0.5, 1.0, and 1.5% end-tidal halothane induced dose-related increases in left ventricular volume and decreases in left ventricular performance in seven normal unpremedicated subjects. During controlled respiration with normocarbia, the diastolic minor axis of the heart, which is related to the cube root of left ventricular volume, increased to a maximum of 107. 7 +/- 1.9 (% +/- SE of control) at 1.5% end-tidal halothane from a control value of 43.5 +/- 1.3 (mm +/- SE). Two ejection-phase performance variables, percentage shortening and mean velocity of circumferential shortening decreased to 60.1 +/- 6.1 (% +/- SE of control) and 62.4 +/- 6.5, (% +/- SE of control) at 1.5% halothane from respective control values of 29.7 +/- 2.61 (% +/- SE) and 0.94 +/- 0.08 (circumferences/second +/- SE). Surgical stimulation did not significantly affect these changes. Under these experimental conditions, we conclude that halothane dilates the heart, and that echocardiography can be used to monitor the depressant effect of halothane on the heart.
J I Gerson; C G Gianaris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  58     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:    1979 Jan-Feb
Date Detail:
Created Date:  1979-06-26     Completed Date:  1979-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Inhalation
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Cardiac Volume / drug effects*
Depression, Chemical
Dose-Response Relationship, Drug
Halothane / pharmacology*
Heart / drug effects*
Heart Ventricles / drug effects
Pulse / drug effects
Reg. No./Substance:
124-38-9/Carbon Dioxide; 151-67-7/Halothane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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