Document Detail

Echocardiographic abnormalities and their correlation with bronchiectasis score in primary antibody deficiencies.
MedLine Citation:
PMID:  19918187     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primary antibody deficiencies are characterized by defective antibody production and recurrent infections. Patients usually present with recurrent respiratory tract infections with consequent chronic pulmonary damage and bronchiectasis, which could potentially influence cardiac function. Our aim was to assess noninvasively the cardiac complications due to pulmonary disease in patients with primary antibody deficiency. METHODS: A cross-sectional series of patients with primary antibody deficiency syndromes from our referral immunology center were recruited. Individuals undergoing high-resolution computed tomography (HRCT) and transthoracic echocardiography were reviewed. RESULTS: Thirty primary immunodeficient patients aged 5-55 years of age (21 males and 9 females) were enrolled in this study. Half of the patients (50%) were found to have bronchiectasis in HRCT imaging. In echocardiographic examination, 20 patients (67%) had at least one abnormality; among which pulmonary hypertension was the most common (33%). Patients with bronchiectasis had higher pulmonary artery pressures and HRCT bronchiectasis score was strongly correlated with pulmonary artery pressure (regression R = 0.59, P value = 0.001). CONCLUSION: Echocardiographic evaluation of right ventricular function and noninvasive estimation of pulmonary artery pressure could have an important diagnostic role in the follow-up and therapeutic management of patients with primary immune deficiency.
Ali Akbar Zeinaloo; Asghar Aghamohammadi; Reza Shabanian; Ali Salavati; Sina Abdollahzade; Nima Rezaei; Hooman Alizadeh; Keyhan Sayadpour Zanjani; Abdolrazagh Kiani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  11     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  IM    
Growth and Development Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Bronchiectasis / etiology*
Child, Preschool
Cross-Sectional Studies
Heart Diseases / etiology*,  ultrasonography
Immunologic Deficiency Syndromes / complications*,  ultrasonography
Lung Diseases / complications*
Middle Aged
Young Adult

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