| Echocardiographic abnormalities in sickle cell disease. | |
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MedLine Citation:
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PMID: 15224351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Echocardiographic abnormalities in patients with sickle cell disease (SCD) were determined, and pulmonary arterial systolic pressure (PASP) was estimated. Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact test was performed to determine correlation between pulmonary hypertension and various clinical variables. Pulmonary hypertension was the most common abnormality identified in 22 (58%) patients. The estimated mean PASP was 37.5 +/- 10.9 mmHg. Older age and prior history of acute chest syndrome were significantly correlated with an increased prevalence of pulmonary hypertension (P < 0.05). Patients with hemoglobin levels <8 g/dL had PASP 43.2 +/- 0.5 compared to a mean PASP of 33.3 +/- 6.0 in patients with hemoglobin > or =8 g/dL (P = 0.01). Eight (21%) patients had evidence of a hyperdynamic left ventricle. Left heart abnormalities included dilated atrium in 14 (37%), dilated ventricle in 5 (13%), ventricle hypertrophy in 5 (13%), and ventricle dysfunction in 3 (9%) patients. Right heart abnormalities included dilated atrium in 9 (24%), dilated ventricle in 6 (16%), and ventricle dysfunction in 3 (9%) patients. Despite an increased incidence of abnormal flow across the valves on Doppler analysis, no patient had structurally abnormal valves. A majority of patients with SCD had evidence of pulmonary hypertension, which correlated with older age and history of acute chest syndrome. Other structural and functional echocardiographic abnormalities were less common. |
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Authors:
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Shahid Ahmed; Anita K Siddiqui; Adnan Sadiq; Rabia K Shahid; Dilip V Patel; Linda A Russo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 76 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-29 Completed Date: 2004-08-02 Revised Date: 2005-03-10 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 195-8 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. shahidahmed00@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Sickle Cell / complications, physiopathology, ultrasonography* Cardiovascular Diseases / epidemiology*, etiology, ultrasonography Echocardiography* Female Heart Atria / ultrasonography Hemoglobins / analysis Humans Hypertension, Pulmonary / epidemiology, ultrasonography Hypertrophy, Left Ventricular / epidemiology, ultrasonography Male Middle Aged Mitral Valve Insufficiency / epidemiology, ultrasonography Tricuspid Valve Insufficiency / epidemiology, ultrasonography Ventricular Dysfunction, Left / epidemiology, ultrasonography Ventricular Dysfunction, Right / epidemiology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
| Comments/Corrections | |
Comment In:
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Am J Hematol. 2005 Feb;78(2):160-1
[PMID:
15682404
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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