| Echinacoside retards cellular senescence of human fibroblastic cells MRC-5. | |
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MedLine Citation:
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PMID: 20099521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, effects of echinacoside, one of the phenylethanoids isolated from the stems of Cistanches salsa, a Chinese traditional herbal medicine, on human embryo lung fibroblastic MRC-5 cells, was investigated. Activity of cell proliferation was evaluated with Alamar Blue, showing that treatment with echinacoside could retard the senescence. Flow cytometry results show that echinacoside could trigger cells in the G1 phase to enter the S phase and G2 phase, and could improve ROS degradation. The results from comet assay indicate that echinacoside could protect cells from DNA damage, partly elucidating the mechanism of its effects. All of the above results suggest that echinacoside has potential anti-senescence activity. |
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Authors:
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Hong Xie; Hui Zhu; Cong Cheng; Yu Liang; Zhao Wang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 64 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2010-01-26 Completed Date: 2010-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 752-4 Citation Subset: IM |
Affiliation:
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Protein Science Key Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, School of Medicine, Tsinghua University, Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Aging
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drug effects* Cell Line Cell Survival Cistanche Coloring Agents Comet Assay DNA Damage Fibroblasts / drug effects*, metabolism Flow Cytometry G1 Phase / drug effects G2 Phase / drug effects Glycosides / pharmacology* Humans Lung / cytology Reactive Oxygen Species / metabolism S Phase / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Glycosides; 0/Reactive Oxygen Species; 82854-37-3/echinacoside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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