| Eccrine angiomatous hamartoma (nevus): immunohistochemical findings and review of the literature. | |
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MedLine Citation:
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PMID: 7514619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eccrine angiomatous hamartoma (nevus) is a rare form of congenital tumorous malformation with proliferation of eccrine secretory coils and ducts, surrounding capillary angiomatous channels and occasionally other minor elements. To date, there have been only about 24 cases reported in the literature. We report an additional case with more detailed description of the microscopic findings, including immunohistochemical observations. The patient was a 28-year-old female who presented with painless, flesh- to reddish brown-colored, violaceous or bluish subcutaneous nodules on the extremities and trunk. The tumors did not show sweating following exertion. The histologic features were comparable to the previously reported cases. The hamartomatous eccrine sweat glands and ducts and a few apocrine glands demonstrated qualitatively diminished antigens commonly found in the eccrine sweat apparatuses, such as carcinoembryonic antigen (CEA) and S-100 protein. The findings of CD34, CD44, human nerve growth factor receptor and Ulex europaeus antigens have not been previously reported. The histologic features suggested a "hamartomatous" growth rather than a true neoplastic process. |
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Authors:
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R L Sulica; G F Kao; V I Sulica; N S Penneys |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 21 ISSN: 0303-6987 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-06-21 Completed Date: 1994-06-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 71-5 Citation Subset: IM |
Affiliation:
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Division of Dermatology, Georgetown University Medical School, Washington, D.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / analysis Antigens, CD34 Antigens, CD44 Carrier Proteins / analysis Eccrine Glands / pathology* Female Hamartoma / metabolism, pathology* Hemangioma / pathology Humans Immunohistochemistry Nevus / chemistry, pathology* Receptors, Cell Surface / analysis Receptors, Lymphocyte Homing / analysis Receptors, Nerve Growth Factor / analysis Sweat Gland Diseases / metabolism, pathology* Sweat Gland Neoplasms / chemistry, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD34; 0/Antigens, CD44; 0/Carrier Proteins; 0/Receptors, Cell Surface; 0/Receptors, Lymphocyte Homing; 0/Receptors, Nerve Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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