Document Detail

Eccrine angiomatous hamartoma (nevus): immunohistochemical findings and review of the literature.
MedLine Citation:
PMID:  7514619     Owner:  NLM     Status:  MEDLINE    
Eccrine angiomatous hamartoma (nevus) is a rare form of congenital tumorous malformation with proliferation of eccrine secretory coils and ducts, surrounding capillary angiomatous channels and occasionally other minor elements. To date, there have been only about 24 cases reported in the literature. We report an additional case with more detailed description of the microscopic findings, including immunohistochemical observations. The patient was a 28-year-old female who presented with painless, flesh- to reddish brown-colored, violaceous or bluish subcutaneous nodules on the extremities and trunk. The tumors did not show sweating following exertion. The histologic features were comparable to the previously reported cases. The hamartomatous eccrine sweat glands and ducts and a few apocrine glands demonstrated qualitatively diminished antigens commonly found in the eccrine sweat apparatuses, such as carcinoembryonic antigen (CEA) and S-100 protein. The findings of CD34, CD44, human nerve growth factor receptor and Ulex europaeus antigens have not been previously reported. The histologic features suggested a "hamartomatous" growth rather than a true neoplastic process.
R L Sulica; G F Kao; V I Sulica; N S Penneys
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  21     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-21     Completed Date:  1994-06-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Division of Dermatology, Georgetown University Medical School, Washington, D.C.
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MeSH Terms
Antigens, CD / analysis
Antigens, CD34
Antigens, CD44
Carrier Proteins / analysis
Eccrine Glands / pathology*
Hamartoma / metabolism,  pathology*
Hemangioma / pathology
Nevus / chemistry,  pathology*
Receptors, Cell Surface / analysis
Receptors, Lymphocyte Homing / analysis
Receptors, Nerve Growth Factor / analysis
Sweat Gland Diseases / metabolism,  pathology*
Sweat Gland Neoplasms / chemistry,  pathology
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD34; 0/Antigens, CD44; 0/Carrier Proteins; 0/Receptors, Cell Surface; 0/Receptors, Lymphocyte Homing; 0/Receptors, Nerve Growth Factor

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