| Eccentric target sign in cerebral toxoplasmosis: neuropathological correlate to the imaging feature. | |
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MedLine Citation:
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PMID: 20512900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral toxoplasmosis remains one of the most common focal brain lesions in patients with acquired immune deficiency syndrome (AIDS). Diagnosis is a challenge because on cranial imaging it closely mimics central nervous system lymphoma, primary and metastatic central nervous system (CNS) tumors, or other intracranial infections like tuberculoma or abscesses. A magnetic resonance imaging (MRI) feature on postcontrast T1-weighted sequences considered pathognomonic of toxoplasmosis is the "eccentric target sign." The pathological correlate of this imaging sign has been speculative. Herein we correlate the underlying histopathology to the MR feature of eccentric target sign in a patient with autopsy-proven HIV/AIDS-related cerebral toxoplasmosis. The central enhancing core of the target seen on MRI was produced by a leash of inflamed vessels extending down the length of the sulcus that was surrounded by concentric zones of necrosis and a wall composed of histiocytes and proliferating blood vessels, with impaired permeability producing the peripheral enhancing rim. |
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Authors:
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G G Sharath Kumar; A Mahadevan; A S Guruprasad; Jerry M E Kovoor; P Satishchandra; Avindra Nath; Udaykumar Ranga; S K Shankar |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-28 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1469-72 Citation Subset: IM |
Affiliation:
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Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Bangalore 560 029, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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diagnosis*,
parasitology Adult Brain / pathology Brain Diseases / parasitology, pathology, virology Cell Proliferation HIV Infections / complications* Humans Magnetic Resonance Imaging / methods Male Permeability Sensitivity and Specificity Tomography, X-Ray Computed / methods Toxoplasmosis, Cerebral / diagnosis, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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1R01NS055628-01A2/NS/NINDS NIH HHS; R01 NS055628-01A2/NS/NINDS NIH HHS |
| Comments/Corrections | |
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