| Eccentric exercise induces chronic alterations in musculoskeletal nociception in the rat. | |
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MedLine Citation:
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PMID: 20726881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eccentric muscle exercise is a common cause of acute and chronic (lasting days to weeks) musculoskeletal pain. To evaluate the mechanisms involved, we have employed a model in the rat, in which eccentric hind limb exercise produces both acute mechanical hyperalgesia as well as long-term changes characterized by enhanced hyperalgesia to subsequent exposure to an inflammatory mediator. Eccentric exercise of the hind limb produced mechanical hyperalgesia, measured in the gastrocnemius muscle, which returned to baseline at 120 h post-exercise. When nociceptive thresholds had returned to baseline, intramuscular injection of prostaglandin E(2) (PGE(2) ) induced hyperalgesia that was unattenuated 240 h later, much longer than PGE(2) -induced hyperalgesia in unexercised rats (4 h). This marked prolongation of PGE(2) hyperalgesia induced by eccentric exercise was prevented by the spinal intrathecal injection of oligodeoxynucleotide antisense to protein kinase Cε, a second messenger in nociceptors implicated in the induction of chronic pain. Exercise-induced hyperalgesia and prolongation of PGE(2) hyperalgesia were inhibited by the spinal intrathecal administration of antisense for the interleukin-6 but not the tumor necrosis factor α type 1 receptor. These findings provide further insight into the mechanism underlying exercise-induced chronic muscle pain, and suggest novel approaches for the prevention and treatment of exercise- or work-related chronic musculoskeletal pain syndromes. |
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Authors:
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Pedro Alvarez; Jon D Levine; Paul G Green |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-19 |
Journal Detail:
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Title: The European journal of neuroscience Volume: 32 ISSN: 1460-9568 ISO Abbreviation: Eur. J. Neurosci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2011-03-01 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 8918110 Medline TA: Eur J Neurosci Country: France |
Other Details:
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Languages: eng Pagination: 819-25 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. |
Affiliation:
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Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94143-0440, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dinoprostone / pharmacology Disease Models, Animal Hindlimb / drug effects, physiopathology Hyperalgesia / chemically induced, drug therapy, metabolism*, physiopathology Interleukin-6 / antagonists & inhibitors Male Muscle, Skeletal / physiopathology Musculoskeletal Diseases / drug therapy, metabolism*, physiopathology Oligodeoxyribonucleotides, Antisense / pharmacology, therapeutic use Pain / drug therapy, metabolism*, physiopathology Physical Conditioning, Animal / physiology* Protein Kinase C-epsilon / antagonists & inhibitors Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha / antagonists & inhibitors |
| Grant Support | |
ID/Acronym/Agency:
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AR054635/AR/NIAMS NIH HHS; P01 NS053709-05/NS/NINDS NIH HHS; R01 AR054635-04/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Oligodeoxyribonucleotides, Antisense; 0/Tumor Necrosis Factor-alpha; 363-24-6/Dinoprostone; EC 2.7.11.13/Protein Kinase C-epsilon |
| Comments/Corrections | |
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