Document Detail

Eccentric exercise induces chronic alterations in musculoskeletal nociception in the rat.
MedLine Citation:
PMID:  20726881     Owner:  NLM     Status:  MEDLINE    
Eccentric muscle exercise is a common cause of acute and chronic (lasting days to weeks) musculoskeletal pain. To evaluate the mechanisms involved, we have employed a model in the rat, in which eccentric hind limb exercise produces both acute mechanical hyperalgesia as well as long-term changes characterized by enhanced hyperalgesia to subsequent exposure to an inflammatory mediator. Eccentric exercise of the hind limb produced mechanical hyperalgesia, measured in the gastrocnemius muscle, which returned to baseline at 120 h post-exercise. When nociceptive thresholds had returned to baseline, intramuscular injection of prostaglandin E(2) (PGE(2) ) induced hyperalgesia that was unattenuated 240 h later, much longer than PGE(2) -induced hyperalgesia in unexercised rats (4 h). This marked prolongation of PGE(2) hyperalgesia induced by eccentric exercise was prevented by the spinal intrathecal injection of oligodeoxynucleotide antisense to protein kinase Cε, a second messenger in nociceptors implicated in the induction of chronic pain. Exercise-induced hyperalgesia and prolongation of PGE(2) hyperalgesia were inhibited by the spinal intrathecal administration of antisense for the interleukin-6 but not the tumor necrosis factor α type 1 receptor. These findings provide further insight into the mechanism underlying exercise-induced chronic muscle pain, and suggest novel approaches for the prevention and treatment of exercise- or work-related chronic musculoskeletal pain syndromes.
Pedro Alvarez; Jon D Levine; Paul G Green
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-08-19
Journal Detail:
Title:  The European journal of neuroscience     Volume:  32     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2011-03-01     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  819-25     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94143-0440, USA.
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MeSH Terms
Dinoprostone / pharmacology
Disease Models, Animal
Hindlimb / drug effects,  physiopathology
Hyperalgesia / chemically induced,  drug therapy,  metabolism*,  physiopathology
Interleukin-6 / antagonists & inhibitors
Muscle, Skeletal / physiopathology
Musculoskeletal Diseases / drug therapy,  metabolism*,  physiopathology
Oligodeoxyribonucleotides, Antisense / pharmacology,  therapeutic use
Pain / drug therapy,  metabolism*,  physiopathology
Physical Conditioning, Animal / physiology*
Protein Kinase C-epsilon / antagonists & inhibitors
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Grant Support
Reg. No./Substance:
0/Interleukin-6; 0/Oligodeoxyribonucleotides, Antisense; 0/Tumor Necrosis Factor-alpha; 363-24-6/Dinoprostone; EC Kinase C-epsilon

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