Document Detail


Eccentric exercise-induced muscle damage impairs muscle glycogen repletion.
MedLine Citation:
PMID:  3624128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five healthy untrained young male subjects were studied before, immediately after, and 10 days after a 45-min bout of eccentric exercise on a cycle ergometer (201 W). The subjects were sedentary at all other times and consumed a eucaloric meat-free diet. Needle biopsies of the vastus lateralis muscle were examined for intracellular damage and glycogen content. Immediately after exercise, muscle samples showed myofibrillar tearing and edema. At 10 days, there was myofibrillar necrosis, inflammatory cell infiltration, and no evidence of myofibrillar regeneration. Glycogen utilization during the exercise bout was 33 mmol glycosyl units/kg muscle, consistent with the metabolic intensity of 44% of maximal O2 uptake; however, the significant glycogen use by type II fibers contrasted with concentric exercise performed at this intensity. At 10 days after exercise, muscle glycogen was still depleted, in both type I and II fibers. It is possible that the alterations in muscle ultrastructures were related to the lack of repletion of muscle glycogen. Damage produced by eccentric exercise was more persistent than previously reported, indicating that more than 10 days may be necessary for recovery of muscle ultrastructure and carbohydrate reserves.
Authors:
K P O'Reilly; M J Warhol; R A Fielding; W R Frontera; C N Meredith; W J Evans
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  63     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-25     Completed Date:  1987-09-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  252-6     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Glycogen / metabolism*
Humans
Kinetics
Male
Microscopy, Electron
Muscles / metabolism,  pathology,  ultrastructure*
Physical Exertion*
Time Factors
Chemical
Reg. No./Substance:
9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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