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Eccentric Exercise Increases Satellite Cell Content in Type II Muscle Fibers.
MedLine Citation:
PMID:  22968308     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Satellite cells (SCs) are of key importance in skeletal muscle tissue growth, repair and regeneration. A single bout of high-force eccentric exercise has been demonstrated to increase mixed muscle satellite cell (SC) content following 1-7 d of post-exercise recovery. However, little is known about fiber type specific changes in SC content and their activation status within 24 h of post-exercise recovery. METHODS: Nine recreationally active young men (23±1 y) performed 300 eccentric actions of the knee extensors on an isokinetic dynamometer. Skeletal muscle biopsies from the vastus lateralis were collected pre- and 24 h post-exercise. Muscle fiber type specific SC content and the number of activated SCs were determined by immunohistochemical analyses. RESULTS: There was no difference between type I and II muscle fiber SC content prior to exercise. SC content significantly increased 24 h post-exercise in type II muscle fibers (from 0.085±0.012 to 0.133±0.016 SCs per fiber, respectively; P<0.05) whereas there was no change in type I fibers. In accordance, activation status increased from preto 24 h post-exercise as demonstrated by the increase in the number of DLK1+ SCs in type II muscle fibers (from 0.027±0.008 to 0.070±0.017 SCs per muscle fiber P<0.05). Although no significant changes were observed in the number of Ki-67+ SCs, we did observe an increase in the number of PCNA+ SCs after 24 h of post-exercise recovery. CONCLUSION: A single bout of high-force eccentric exercise increases muscle fiber SC content and activation status in type II but not type I muscle fibers.
Authors:
Naomi M Cermak; Tim Snijders; Bryon R McKay; Gianni Parise; Lex B Verdijk; Mark A Tarnopolsky; Martin J Gibala; Luc J C van Loon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-10
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands. 2Exercise Metabolism Research Group, Department of Kinesiology, McMaster University; Hamilton, Ontario, Canada; 3Department of Pediatrics and Medicine, McMaster University; Hamilton, Ontario, Canada.
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