| Ebselen attenuates cadmium-induced testicular damage in mice. | |
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MedLine Citation:
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PMID: 17624921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to examine if ebselen, an organoselenium compound with antioxidant and glutathione peroxidase-mimetic properties, attenuates testicular injury caused by intraperitoneal administration of CdCl(2). A number of toxicological parameters were evaluated in the testes of mice, such as delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, lipid peroxidation, ascorbic acid levels and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Ebselen attenuated lipid peroxidation levels altered by CdCl(2). delta-ALA-D activity inhibited by the highest dose of CdCl(2) was attenuated by ebselen. A significant negative correlation between lipid peroxidation levels and delta-ALA-D activity was observed. Ebselen restored ascorbic acid levels reduced by CdCl(2). A significant negative correlation between ascorbic acid levels and delta-ALA-D activity reinforces the idea that ebselen attenuated the damage induced by CdCl(2) via its antioxidant property. The significant correlation between ALT and delta-ALA-D activity supports the assumption that ebselen prevented damage caused by CdCl(2). The results show that ebselen attenuated oxidative stress, a process important for CdCl(2) toxicity. |
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Authors:
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Ana P Ardais; Francielli W Santos; Cristina W Nogueira |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 28 ISSN: 0260-437X ISO Abbreviation: J Appl Toxicol Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-27 Completed Date: 2008-06-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 322-8 Citation Subset: IM |
Affiliation:
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Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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metabolism Animals Antioxidants / therapeutic use* Ascorbic Acid / metabolism Aspartate Aminotransferases / metabolism Azoles / therapeutic use* Biological Markers / metabolism Cadmium Chloride / toxicity* Disease Models, Animal Drug Antagonism Injections, Intraperitoneal Lipid Peroxidation / drug effects Male Mice Organoselenium Compounds / therapeutic use* Porphobilinogen Synthase / metabolism Testicular Diseases / chemically induced, metabolism, prevention & control* Testis / drug effects*, metabolism Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Azoles; 0/Biological Markers; 0/Organoselenium Compounds; 0/Thiobarbituric Acid Reactive Substances; 10108-64-2/Cadmium Chloride; 50-81-7/Ascorbic Acid; 60940-34-3/ebselen; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 4.2.1.24/Porphobilinogen Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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