Document Detail


Ebselen attenuates cadmium-induced testicular damage in mice.
MedLine Citation:
PMID:  17624921     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to examine if ebselen, an organoselenium compound with antioxidant and glutathione peroxidase-mimetic properties, attenuates testicular injury caused by intraperitoneal administration of CdCl(2). A number of toxicological parameters were evaluated in the testes of mice, such as delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, lipid peroxidation, ascorbic acid levels and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Ebselen attenuated lipid peroxidation levels altered by CdCl(2). delta-ALA-D activity inhibited by the highest dose of CdCl(2) was attenuated by ebselen. A significant negative correlation between lipid peroxidation levels and delta-ALA-D activity was observed. Ebselen restored ascorbic acid levels reduced by CdCl(2). A significant negative correlation between ascorbic acid levels and delta-ALA-D activity reinforces the idea that ebselen attenuated the damage induced by CdCl(2) via its antioxidant property. The significant correlation between ALT and delta-ALA-D activity supports the assumption that ebselen prevented damage caused by CdCl(2). The results show that ebselen attenuated oxidative stress, a process important for CdCl(2) toxicity.
Authors:
Ana P Ardais; Francielli W Santos; Cristina W Nogueira
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  28     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  322-8     Citation Subset:  IM    
Affiliation:
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / metabolism
Animals
Antioxidants / therapeutic use*
Ascorbic Acid / metabolism
Aspartate Aminotransferases / metabolism
Azoles / therapeutic use*
Biological Markers / metabolism
Cadmium Chloride / toxicity*
Disease Models, Animal
Drug Antagonism
Injections, Intraperitoneal
Lipid Peroxidation / drug effects
Male
Mice
Organoselenium Compounds / therapeutic use*
Porphobilinogen Synthase / metabolism
Testicular Diseases / chemically induced,  metabolism,  prevention & control*
Testis / drug effects*,  metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Azoles; 0/Biological Markers; 0/Organoselenium Compounds; 0/Thiobarbituric Acid Reactive Substances; 10108-64-2/Cadmium Chloride; 50-81-7/Ascorbic Acid; 60940-34-3/ebselen; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 4.2.1.24/Porphobilinogen Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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